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Table 4 Power to detect an association under genetic model A (defined by x = 1 and s = 0.5 for the relative penetrances of heterozygous carrier of the DS allele and non carrier)

From: Selection of SNP subsets for association studies in candidate genes: comparison of the power of different strategies to detect single disease susceptibility locus effects

A – IL13
Method selected SNPs mean power for Model A
    haplo. testsd SL testse
I (Johnson et al.) 1, 4, 9, 11, 15, 16 included DSLa 0.739 0.825
   excluded DSLb 0.597 0.504
   all possible DSLc 0.650 0.624
II (Stram et al) 1, 3, 4, 5, 7, 8, 10, 11, 13, 15, 16 included DSL 0.600 0.749
   excluded DSL 0.620 0.627
   all possible DSL 0.606 0.710
III (Cousin et al.) 1, 3, 4, 5, 7, 8, 11, 13, 14, 15, 16 included DSL 0.579 0.694
   excluded DSL 0.739 0.767
   all possible DSL 0.628 0.716
IV 0.5 (Carlson et al.) 1, 3, 4, 5, 6, 7, 10, 14, 15, 16 included DSL 0.526 0.612
   excluded DSL 0.905 0.914
   all possible DSL 0.668 0.725
IV 0.8 (Carlson et al.) 1, 3, 4, 5, 6, 7, 8, 13, 14, 15, 16 included DSL 0.573 0.637
   excluded DSL 0.914 0.946
   all possible DSL 0.679 0.734
B – TNF
Method selected SNPs mean power for Model A
    haplo. testsd SL testse
I (Johnson et al.) 1, 2, 5, 12 included DSLa 0.909 0.930
   excluded DSLb 0.914 0.930
   all possible DSLc 0.908 0.926
II (Stram et al) 1, 4, 5, 6, 12 included DSL 0.899 0.928
   excluded DSL 0.893 0.921
   all possible DSL 0.896 0.924
III (Cousin et al.) 1, 2, 4 included DSL 0.958 0.966
   excluded DSL 0.857 0.866
   all possible DSL 0.882 0.891
IV 0.5 (Carlson et al.) 2, 4, 5, 10 included DSL 0.902 0.922
   excluded DSL 0.910 0.925
   all possible DSL 0.908 0.924
IV 0.8 (Carlson et al.) 1, 2, 4, 5, 10, 12 included DSL 0.911 0.932
   excluded DSL 0.880 0.910
   all possible DSL 0.896 0.921
  1. aSNP included in the selected subset and considered as Disease Susceptibility Locus
  2. bSNP excluded from the selected subset and considered as Disease Susceptibility Locus
  3. call the possible Disease Susceptibility Loci (within or outside of the subset)
  4. dhaplotype tests
  5. eSingle Locus tests