Table 4 Power to detect an association under genetic model A (defined by x = 1 and s = 0.5 for the relative penetrances of heterozygous carrier of the DS allele and non carrier)

haplo. tests^d

SL tests^e

I (Johnson et al.)

1, 4, 9, 11, 15, 16

included DSL^a

0.739

0.825

excluded DSL^b

0.597

0.504

all possible DSL^c

0.650

0.624

II (Stram et al)

1, 3, 4, 5, 7, 8, 10, 11, 13, 15, 16

included DSL

0.600

0.749

excluded DSL

0.620

0.627

all possible DSL

0.606

0.710

III (Cousin et al.)

1, 3, 4, 5, 7, 8, 11, 13, 14, 15, 16

included DSL

0.579

0.694

excluded DSL

0.739

0.767

all possible DSL

0.628

0.716

IV 0.5 (Carlson et al.)

1, 3, 4, 5, 6, 7, 10, 14, 15, 16

included DSL

0.526

0.612

excluded DSL

0.905

0.914

all possible DSL

0.668

0.725

IV 0.8 (Carlson et al.)

1, 3, 4, 5, 6, 7, 8, 13, 14, 15, 16

included DSL

0.573

0.637

excluded DSL

0.914

0.946

all possible DSL

0.679

0.734

B – TNF

Method

selected SNPs

mean power for

Model A

haplo. tests^d

SL tests^e

I (Johnson et al.)

1, 2, 5, 12

included DSL^a

0.909

0.930

excluded DSL^b

0.914

0.930

all possible DSL^c

0.908

0.926

II (Stram et al)

1, 4, 5, 6, 12

included DSL

0.899

0.928

excluded DSL

0.893

0.921

all possible DSL

0.896

0.924

III (Cousin et al.)

1, 2, 4

included DSL

0.958

0.966

excluded DSL

0.857

0.866

all possible DSL

0.882

0.891

IV 0.5 (Carlson et al.)

2, 4, 5, 10

included DSL

0.902

0.922

excluded DSL

0.910

0.925

all possible DSL

0.908

0.924

IV 0.8 (Carlson et al.)

1, 2, 4, 5, 10, 12

included DSL

0.911

0.932

excluded DSL

0.880

0.910

all possible DSL

0.896

0.921