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Table 4 Putative candidate genes in candidate QTL regions for inguinal and scrotal hernias. The most promising regions on SSC1, SSC2, SSC5, SSC6, SSC7, SSC15 and SSC17 are shown, as well as the homologous regions in human.

From: Genome-wide linkage analysis of inguinal hernia in pigs using affected sib pairs

QTL region1 Homologous regions in human2 Putative candidate genes
SSC1 p25 – q14 HSA6 q25 Collagen typeIXα (COL9A1), Estrogen receptor 1 (ESR1)
  HSA18 p11.2 – p11.32  
SSC2 p14 – q23 HSA5 q12 – q35  
  HSA11 q13 – p15 Calcitonin gene-related peptide (CGRP)
  HSA19 p13.1 – p13.3 Insulin like hormone 3 (INSL3), Mullerian-inhibiting substance (MIS)
SSC5 q11 – q22 HSA12 q11.2 – p13 Collagen type II (COL2A1)
SSC6 q27 – q32 HSA1 p22 – p36.3 Insulin-like hormone 5 (INSL5)
  HSA18 q12 – p11.32  
SSC7 q11 – q15 HSA15 q12 – q26 Cytochrome P450, family19A1 (CYP19A1)
SSC7 q24 – q26 HSA14 q11.2 – q32  
SSC15 HSA2 q11.2 – q21  
SSC17 p11 and p21 HSA5 and HSA20  
  1. 1Based on the cytogenetic maps we suggest where the microsatellite markers are physically mapped to the porcine genome [48,49]
  2. 2This is seen from comparative mapping between pig and human [24,25,26,27,50]