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Table 1 BRCA2 and MRE11 mutations in MIN cell lines

From: Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE11?: Considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers

Tumor Cell Line/Xenograft*

Truncating BRCA2 Mutations

Other BRCA2 Variants

MRE11A Mutations**

MIP101 (colorectal)

5355delA, 3599delGT

R2784G

T9/T10/T11

LS174T (colorectal)

9110delA

 

T9/T10

RKO (colorectal)

5355delA

 

T8/T9/T10

HCT116 (colorectal)

9110delA

 

T9/T10

KM12 (colorectal)

5355delA

K1565N

 

PL3 (pancreatic)

5073delA

 

T9/T10

PL5 (pancreatic)

None detected

 

T9/T10

PX196 (pancreatic)

1813delA

S326R

 

Vaco481 (colorectal)

None detected

I2944F, K1777del3

 
  1. *Six additional MSI cell lines had no truncating mutation or other variant of the BRCA2 sequence.
  2. **Nucleotide deletions of the [T]11 tract. The mutations in LS174T, MIP101, and HCT116 were reported previously [18, 22, 23]
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BMC Genomic Data

ISSN: 2730-6844

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