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Table 1 Summary of Dlk1-Gtl2 expression and imprinting in Gtl2lacZ and Gtl2Δ5'Neo mice.

From: Loss of imprinting at the Dlk1-Gtl2 locus caused by insertional mutagenesis in the Gtl2 5' region

 

Dlk1

 

Gtl2

 
 

Expression

Imprinting

Expression

Imprinting

Gtl2lacZPat 129

52%

No change

127%

Biallelic

Gtl2lacZPat B 6

No change

No change

No change

No change

Gtl2lacZMat 129

131%

Biallelic

50%

No change

Gtl2lacZMat B 6

127%

Biallelic

60%

No change

 

Dlk1

 

Gtl2

 
 

Expression

Imprinting

Expression

Imprinting

Gtl2Δ5'NeoPat 129

60%

No change

132%

Biallelic

Gtl2Δ5'NeoPat B 6

35%

No change

160%

Biallelic

Gtl2Δ5'NeoMat 129

108%

Biallelic

83%

No change

Gtl2Δ5'NeoMat B 6

127%

Biallelic

55%

No change

  1. The column "Expression" gives percent change in mRNA levels relative to wild type littermates; "No change" indicates that there is no deviation in expression from wild type. The column "Imprinting" indicates that imprinting is maintained ("No change") or that the silent allele of a given gene is activated ("biallelic").