Skip to main content

Table 1 Summary of Dlk1-Gtl2 expression and imprinting in Gtl2lacZ and Gtl2Δ5'Neo mice.

From: Loss of imprinting at the Dlk1-Gtl2 locus caused by insertional mutagenesis in the Gtl2 5' region

  Dlk1   Gtl2  
  Expression Imprinting Expression Imprinting
Gtl2lacZPat 129 52% No change 127% Biallelic
Gtl2lacZPat B 6 No change No change No change No change
Gtl2lacZMat 129 131% Biallelic 50% No change
Gtl2lacZMat B 6 127% Biallelic 60% No change
  Dlk1   Gtl2  
  Expression Imprinting Expression Imprinting
Gtl2Δ5'NeoPat 129 60% No change 132% Biallelic
Gtl2Δ5'NeoPat B 6 35% No change 160% Biallelic
Gtl2Δ5'NeoMat 129 108% Biallelic 83% No change
Gtl2Δ5'NeoMat B 6 127% Biallelic 55% No change
  1. The column "Expression" gives percent change in mRNA levels relative to wild type littermates; "No change" indicates that there is no deviation in expression from wild type. The column "Imprinting" indicates that imprinting is maintained ("No change") or that the silent allele of a given gene is activated ("biallelic").