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Table 2 Empirical type I error rate of the proposed test at the nominal 5% level when population stratification exists. A diallelic marker is completely linked to the QTL with HW equilibrium in an admixed population. Total 500 sibpairs (250/250) are selected from two subpopulations. p1 and p1 are frequencies of the rarer marker allele in the two subpopulations. d is the difference in trait means between two subpopulations.

From: A quantitative linkage score for an association study following a linkage analysis

p1 - p2

d = 10

d = 20

 

Linkage

Association-Linkage

Population stratification

Linkage

Association-Linkage

Population stratification

0.4

0.200

0.00055

0.403

0.165

0

0.758

0.3

0.191

0.0016

0.311

0.166

0

0.536

0.2

0.200

0.0054

0.177

0.159

0.001

0.283

0.1

0.192

0.025

0.084

0.154

0.012

0.106

0

0.194

0.050

0.019

0.150

0.047

0.013