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Table 2 Association analysis in the 1,693 T1D patients and 1,805 controls from the UK.

From: Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11

Gene Allele Type 1 diabetes patients Controls MAF   
Polymorphism 1/2 11 (%) 12 (%) 22 (%) 11 (%) 12 (%) 22 (%) T1D Controls OR for allele 1 (95% CI) P-value
PAPD1            
rs2480285 G/A 82 (5.0) 544 (33.4) 1002 (61.5) 59 (3.4) 600 (34.9) 1060 (61.7) 0.22 0.21 1.05 (0.94 – 1.18) 0.39
ss48399025 A/C 1375 (81.4) 296 (17.5) 19 (1.1) 1469 (81.4) 326 (18.1) 10 (0.6) 0.10 0.1 0.97 (0.83 – 1.13) 0.68
ss48399034 A/T 1528 (90.6) 155 (9.2) 3 (0.2) 1620 (92.3) 133 (7.6) 2 (0.1) 0.05 0.04 0.81 (0.64 – 1.02) 0.076
ss48399036 A/G 0 (0.0) 64 (3.8) 1629 (96.2) 0 (0.0) 60 (3.3) 1734 (96.7) 0.02 0.02 1.13 (0.79 – 1.62) 0.49
rs1963187 A/T 1457 (89.1) 170 (10.4) 8 (0.5) 1564 (89.6) 175 (10.0) 7 (0.4) 0.06 0.05 0.95 (0.77 – 1.17) 0.62
D10S193 226/non 226 21 (1.3) 293 (18.5) 1270 (80.2) 15 (1.0) 261 (16.6) 1297 (82.5) 0.11 0.09 1.16 (0.98 – 1.37) 0.078
D10S193 228/non 228 4 (0.3) 158 (10.0) 1422 (89.8) 13 (0.8) 195 (12.4) 1365 (86.8) 0.05 0.07 0.73 (0.59 – 0.90) 0.0031
NRP1            
rs1048804 A/G 962 (57.7) 605 (36.3) 100 (6.0) 1068 (59.9) 636 (35.7) 80 (4.5) 0.24 0.22 0.9 (0.81 – 1.01) 0.071
MYO3A            
rs1339816 A/G 183 (11.3) 686 (42.3) 751 (46.4) 190 (11.2) 731 (43.1) 774 (45.7) 0.32 0.33 0.99 (0.89 – 1.09) 0.79
rs2096176 A/G 312 (18.7) 790 (47.2) 570 (34.1) 310 (17.5) 872 (49.1) 593 (33.4) 0.42 0.42 1.01 (0.92 – 1.11) 0.83
HNRPF            
rs1416226 A/G 101 (6.1) 574 (34.4) 993 (59.5) 91 (5.2) 629 (36.0) 1028 (58.8) 0.23 0.23 1.0 (0.90 – 1.12) 0.95
SVIL            
rs2274494 A/G 230 (13.7) 784 (46.9) 659 (39.4) 214 (12.2) 847 (48.2) 698 (39.7) 0.37 0.36 1.04 (0.94 – 1.15) 0.42
rs11600 T/C 32 (1.9) 372 (22.3) 1261 (75.7) 25 (1.4) 397 (22.3) 1362 (76.3) 0.13 0.13 1.05 (0.91 – 1.21) 0.48
Intergenic            
rs787025 T/G 8 (0.5) 226 (13.6) 1433 (86.0) 6 (0.3) 237 (13.2) 1549 (86.4) 0.07 0.07 1.05 (0.87 – 1.26) 0.62
  1. Abbreviations: CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; SNP, single nucleotide polymorphism.