Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group

Table 1 CMAH DNA variants genotyped in domestic cats.

	Blood		5' UTR			E2	E3	E13
Breed	Type¹	No.	A-217G	C-371T	Δ-53	G139A	T265A	G1600A
Trace archive			A	A	N	G	T	G
Birman³	A	18	AA	CC	NN	GG	TT	GG
British SH³	A	5	AA	CC	NN	GG	TT	GG
Devon Rex³	A	5	AA	CC	NN	GG	TT	GG
Domestic SH³	A	1	AA	CC	NN	GG	TT	GG
Exotic SH	A	3	AA	CC	NN	GG	TT	GG
Oriental SH⁴	A	1	AA	CC	NN	GG	TT	GG
Scottish Fold	A	2	AA	CC	NN	GG	TT	GG
Type A Haplotype			A	C	N	G	T	G
Birman	A	19	AG	CT	NP	GA	TA	GA
British SH	A	14	AG	CT	NP	GA	TA	GA
Devon Rex	A	18	AG	CT	NP	GA	TA	GA
Domestic SH	A	1	AG	CT	NP	GA	TA	GA
Exotic SH	A	1	AG	CT	NP	GA	TA	GA
Hybrid⁴	Ab	12	AG	CT	NP	GA	TA	GA
Scottish Fold	A	5	AG	CT	NP	GA	TA	GA
Siberian	A	2	AG	CT	NP	GA	TA	GA
Birman³	B	22	GG	TT	PP	AA	AA	AA
British SH³	B	30	GG	TT	PP	AA	AA	AA
Devon Rex	B	25	GG	TT	PP	AA	AA	AA
Persian⁴	B	1	GG	TT	PP	AA	AA	AA
Scottish Fold	B	1	GG	TT	PP	AA	AA	AA
Type B haplotype			G	T	P	A	A	A
Bengal	AB	1	AA	CC	NN	GG	TT	GG
Devon Rex	AB	1	AA	CC	NN	GG	TT	GG
Egyptian Mau	AB	1	AA	CC	NN	GG	TT	GG
European	AB	4	AA	CC	NN	GG	TT	GG
Ragdoll	AB	8	AA	CC	NN	GG	TT	GG
Siamese⁴	AB	1	AA	CC	NN	GG	TT	GG
Siberian	AB	1	AA	CC	NN	GG	TT	GG
British SH	AB	3	AG	CT	NP	GA	TA	GA
Cornish Rex	AB	2	AG	CT	NP	GA	TA	GA
Devon Rex	AB	7	AG	CT	NP	GA	TA	GA
European	AB	1	AG	CT	NP	GA	TA	GA
Maine Coon	AB	1	AG	CT	NP	GA	TA	GA
Manx	AB	1	AG	CT	NP	GA	TA	GA
Ragdoll³	AB	1	AG	CT	NP	GA	TA	GA
Sphynx³	AB	2	AG	CT	NN	GA	TA	GA
Totals: 18 breeds		N = 221

The column labels indicate which region of the gene had the mutation, such as the 5' UTR or exons 2, 3, or 13. The actual base pair changes and positions are noted above each column. The delta symbol indicates a deletion. The sequence for the trace archive sequence from GenBank of the Abyssinian cat is listed first. 1. Blood typing was determined as described in the Methods. 2. The 18 bp indel is represented by N for not present and P for present. All other mutations are presented as their nucleotide abbreviation (A = adenine, C = cytosine, T = thymidine, G = guanine). 3. The genomic sequence of each CMAH exon, except exons 4 and 10 was determined for one cat of each of the indicated breeds. 4. The cDNA sequence was determined for one cat of each of the indicated breeds.

ISSN: 2730-6844