A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition

Table 2 SNPs showing a significant (p < 0.01) association with at least one cognitive trait at age 79 (LBC1921), controlling for sex and age 11 cognitive ability.

		No. of subjects with each genotype			Moray House Test			Raven's Progressive Matrices			Verbal Fluency			Logical Memory
Gene	SNP	A/A	A/B	B/B	F	p	η²	F	p	η²	F	p	η²	F	p	η²
APP	rs2830102	46	177	214	5.835	.003	.026	4.163	.016	.019	.023	.978	.000	.831	.436	.004
GLRX	rs4561	160	222	54	1.375	.254	.006	.580	.560	.003	1.712	.182	.008	5.893	.003	.027
HSPA9B	rs10117	66	217	154	5.194	.006	.024	1.563	.211	.007	1.349	.261	.006	1.326	.267	.006
MSRB2	rs7427	53	200	184	5.099	.006	.023	2.212	.111	.010	.722	.487	.003	.598	.550	.003
NDUFS1	rs11548670	412	25	0	1.922	.166	.004	1.281	.258	.003	9.629	.002	.022	1.135	.287	.003
NDUFV2	rs906807	17	134	286	1.063	.346	.005	4.733	.009	.022	.114	.892	.001	.312	.732	.001
NDUFV3	rs4148973	54	196	187	.332	.718	.002	.749	.473	.003	8.379	.0003	.038	.583	.559	.003
NDUFV3	rs8128440	186	195	55	.342	.710	.002	.694	.500	.003	8.816	.0002	.039	.299	.742	.001
NOS1	rs9658446	0	4	433	3.491	.062	.008	1.754	.186	.004	1.334	.249	.003	8.567	.004	.019

ISSN: 2730-6844