Patterns of population differentiation of candidate genes for cardiovascular disease

BMC Genomic Data

Table 3 Genes with a significantly high weighted-average F_ST(P ≤ 0.05)

Symbol	Gene name	YRI vs. CEU		YRI vs. CHB + JPT		CEU vs. CHB + JPT		Biological processes
		F _ST	P	F _ST	P	F _ST	P
GRB2	growth factor receptor-bound protein 2	0.720	0.035*	0.828	0.023*	0.048	0.556	Immune response
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.658	0.043*	0.555	0.071	0.034	0.605	Immune response
IL4	interleukin 4	0.262	0.220	0.205	0.329	0.512	0.043*	Immune response/Apoptosis
IL6	interleukin 6	0.108	0.478	0.431	0.119	0.570	0.037*	Immune response/Apoptosis
ARHGEF1	Rho guanine nucleotide exchange factor 1	0.769	0.030*	0.532	0.078	0.149	0.263	Apoptosis
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.642	0.045*	0.544	0.074	0.070	0.456	Apoptosis
BCL2L1	BCL2-like 1	0.278	0.204	0.679	0.043*	0.265	0.127	Apoptosis
PMVK	phosphomevalonate kinase	0.563	0.059*	0.652	0.048*	0.097	0.380	Lipoprotein metabolism
F2	coagulation factor II	0.413	0.109	0.536	0.077	0.473	0.049*	Blood clotting

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