Classical sickle beta-globin haplotypes exhibit a high degree of long-range haplotype similarity in African and Afro-Caribbean populations

Table 1 SNPs used for haplotype construction in Jamaicans.

rs number^a	Chr loc^a	Dist from HbS (bp)^b	Alleles^c	MAF^d
rs872165	5381108	-176300	C/A	0.29
rs1498468	5367607	-162799	T/C	0.33
rs2647598	5332852	-128044	T/C	0.41
rs7929631	5324552	-119744	T/G	0.33
rs7938837	5319683	-114875	C/G	0.28
rs3898917	5284937	-80129	G/T	0.27
rs3888708	5274956	-70148	C/A	0.89
rs2156918	5253468	-48660	C/G	0.23
rs2855122	5233812	-29004	A/G	0.42
Xmn1	5232745	-27937	-/+	0.10
Hind3	5231293	-26485	-/+	0.44
Hind3	5226375	-21567	-/+	0.12
rs916111	5225919	-21111	A/T	0.17
rs2071348	5220722	-15914	A/C	0.10
Hinc2	5217034	-12226	-/+	0.15
rs16911905	5205866	-1058	G/C	0.29
rs11036364	5205580	-772	A/G	0.24
HbS (rs334)	5204808	0	A/T	0.06
rs4910726	5156896	47912	A/C	0.17
rs4910722	5153293	51515	A/G	0.20
rs4910715	5132596	72212	G/T	0.48
rs2472523	5123701	81107	G/A	0.06
rs2472527	5118600	86208	T/C	0.05
rs7114854	5100498	104310	A/C	0.20
rs17497	5014184	190624	G/C	0.44
rs2499953	4967481	237327	A/G	0.26

^a– rs numbers and location on chromosome 6 (Chr loc) are given with reference to HapMap release #20
^b– Negative distances (Dist) from the HbS allele are upstream (5') of the allele, positive distances are downstream (3')
^c– SNP alleles given as major/minor.
^d– Minor allele frequency.

ISSN: 2730-6844