Table 1 Differentially expressed genes in GAN vs. normal fibroblasts as analyzed by oligonucleotide microarrays. Genes selected displayed at least a three-fold difference in expression level.
Name | Acc. number | Fold change |
|---|---|---|
Genes involved in lipid metabolism and adipogensis | ||
Complement component 3 precursor | NM_000064.1 | 33.67 |
Butyrylcholinesterase | NM_000055 | 20.67 |
Alpha-2,8-sialyltransferase | L32867.1 | 6.95 |
Fatty acid binding protein 5 | NM_001444.1 | 6.48 |
ATP-binding cassette A6 | AA099357 | 4.38 |
Meltrin alpha | W46291 | 5.51 |
Adipsin | NM_001928.1 | -7.39 |
ATP-binding cassette B4 | NM_000443.2 | -9.77 |
Acyl coenzyme A:cholesterol acyltransferase | S73751.1 | -24.91 |
Leptin | NM_000230.1 | -34.35 |
Integral membrane proteins and receptors | ||
GABA-B receptor | AF056085.1 | 8.85 |
Integrin, beta 3 | M35999.1 | 4.89 |
GABA-B receptor R2 | AF095784.1 | 5.05 |
GABA-B receptor splice variant 1 | AF095723.1 | 6.06 |
Orphan G protein-coupled receptor | AF069755.1 | 4.52 |
Integral membrane serine protease | U76833.1 | 4.63 |
Hyaluronan-mediated motility receptor | NM_012485.1 | 3.14 |
Death receptor 6 | BE568134 | -4.14 |
Endothelin receptor | M74921.1 | -5.12 |
P-glycoprotein (mdr1) | AF016535.1 | -7.95 |
Membrane glycoprotein M6 | D49958.1 | -5.82 |
C18ORF1 | NM_004338.1 | -4.19 |
Glycoprotein M6A | BF939489 | -6.68 |
Potassium channel beta subunit | L39833.1 | -5.44 |
Endothelin receptor type B | NM_003991.1 | -8.89 |
Potassium channel beta 1a subunit | U33428.1 | -3.99 |
E-cadherin | NM_004360.1 | -7.04 |
Cell division/proliferation/apoptosis | ||
Survivin | NM_001168.1 | 6.37 |
PDZ-binding kinase | NM_018492.1 | 4.38 |
Survivin-beta | AB028869.1 | 6.53 |
Mitosin (CENPF) | NM_005196.1 | 3.79 |
Dickkopf homolog 1 | NM_012242.1 | 4.59 |
Kinetochore associated 2 | NM_006101.1 | 3.51 |
Cell division cycle 2 | AL524035 | 3.47 |
WNT4 | NM_030761.1 | -4.05 |
Fritz | U91903.1 | -4.83 |
Tumor necrosis factor-related protein | NM_030945.1 | -6.03 |
EGF-like-domain, multiple 6 | NM_015507.2 | -8.22 |
Transcription factors and nuclear proteins | ||
Transcription factor AP-2 alpha | BF343007 | 7.41 |
High mobility group AT-hook 1 | NM_002131.1 | 5.58 |
Nuclear factor IB | AI700518 | 4.49 |
Interferon-inducible protein p78 | NM_002462.2 | 7.57 |
Cytoskeleton | ||
Rabkinesin6 | NM_005733.1 | 4.66 |
Stathmin-like 2 | NM_007029.1 | -5.32 |
Pregnancy specific beta-1-glycoprotein | ||
Pregnancy specific beta-1-glycoprotein 7 | NM_002783.1 | -5.85 |
Pregnancy specific beta-1-glycoprotein 4 | NM_002780.1 | -17.82 |
Pregnancy specific beta-1-glycoprotein 1 | NM_006905.1 | -62.90 |
Uncharacterized genes | ||
Hypothetical protein PRO02730 | AL137654 | 10.56 |
Uncharacterized bone marrow protein | NM_018454.1 | 5.06 |
Hypothetical protein FLJ10517 | NM_018123.1 | 5.74 |
KIAA0101 gene product | NM_014736.1 | 5.10 |
KIAA0008 gene product | NM_014750.1 | 4.62 |
Doublecortin and CaM kinase-like 1 | NM_004734.1 | 4.53 |
KIAA1547 gene product | AW873621 | 3.96 |
Hypothetical protein DKFZp762E1312 | NM_018410.1 | 4.54 |
Hypothetical protein FLJ10829 | NM_018234.1 | 5.12 |
Clone HQ0310 PRO0310p1 | NM_016359.1 | 4.38 |
Hypothetical protein DKFZp564H1916 | AI186739 | 3.69 |
KIAA0042 gene product | NM_014875.1 | 4.96 |
Hypothetical protein FLJ22009 | NM_024745.1 | 4.11 |
Hypothetical protein FLJ23468 | NM_024629.1 | 3.48 |
Hypothetical protein DKFZp564N1116 | BF344237 | 4.03 |
Hypothetical protein FLJ10781 | NM_018215.1 | -3.68 |
Myomegalin | AB042557.1 | -4.97 |
Hypothetical protein DKFZp564B052 | NM_030820.1 | -5.46 |
KIAA0008 gene product | AK002054.1 | -16.44 |
MGC:3052 | BC002449.1 | -7.73 |
KIAA0865 gene product | AI522028 | -7.70 |
Miscellaneous | ||
Matrix metalloproteinase 1 | NM_002421.2 | 7.73 |
Carbonic anhydrase XII | NM_001218.2 | 7.80 |
Topoisomerase II alpha | AU159942 | 6.87 |
Step II splicing factor SLU7 | AV733266 | 6.93 |
Monocyte chemotactic protein | S69738.1 | 4.37 |
Ribonucleotide reductase M2 | BE966236 | 4.59 |
Plasminogen activator, urokinase | NM_002658.1 | 4.19 |
Cathepsin C | NM_001814.1 | 4.34 |
Atrophin-1 interacting protein 1 | NM_012301.1 | -3.89 |
Monoamine oxidase A | AA923354 | -4.77 |
Type II iodothyronine deiodinase | U53506.1 | -2.80 |
Phosphatidylserine-binding protein | NM_004657.1 | -3.98 |
Scrapie responsive protein 1 | NM_007281.1 | -5.72 |
Natural killer cell transcript 4 | NM_004221.1 | -5.94 |
CD24 signal transducer | L33930 | -9.16 |
Elastase 2 | NM_001972.1 | -9.71 |
CD24 antigen | AA761181 | -19.19 |