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Table 1 Differentially expressed genes in GAN vs. normal fibroblasts as analyzed by oligonucleotide microarrays. Genes selected displayed at least a three-fold difference in expression level.

From: Alterations in lipid metabolism gene expression and abnormal lipid accumulation in fibroblast explants from giant axonal neuropathy patients

Name Acc. number Fold change
Genes involved in lipid metabolism and adipogensis
Complement component 3 precursor NM_000064.1 33.67
Butyrylcholinesterase NM_000055 20.67
Alpha-2,8-sialyltransferase L32867.1 6.95
Fatty acid binding protein 5 NM_001444.1 6.48
ATP-binding cassette A6 AA099357 4.38
Meltrin alpha W46291 5.51
Adipsin NM_001928.1 -7.39
ATP-binding cassette B4 NM_000443.2 -9.77
Acyl coenzyme A:cholesterol acyltransferase S73751.1 -24.91
Leptin NM_000230.1 -34.35
Integral membrane proteins and receptors
GABA-B receptor AF056085.1 8.85
Integrin, beta 3 M35999.1 4.89
GABA-B receptor R2 AF095784.1 5.05
GABA-B receptor splice variant 1 AF095723.1 6.06
Orphan G protein-coupled receptor AF069755.1 4.52
Integral membrane serine protease U76833.1 4.63
Hyaluronan-mediated motility receptor NM_012485.1 3.14
Death receptor 6 BE568134 -4.14
Endothelin receptor M74921.1 -5.12
P-glycoprotein (mdr1) AF016535.1 -7.95
Membrane glycoprotein M6 D49958.1 -5.82
C18ORF1 NM_004338.1 -4.19
Glycoprotein M6A BF939489 -6.68
Potassium channel beta subunit L39833.1 -5.44
Endothelin receptor type B NM_003991.1 -8.89
Potassium channel beta 1a subunit U33428.1 -3.99
E-cadherin NM_004360.1 -7.04
Cell division/proliferation/apoptosis
Survivin NM_001168.1 6.37
PDZ-binding kinase NM_018492.1 4.38
Survivin-beta AB028869.1 6.53
Mitosin (CENPF) NM_005196.1 3.79
Dickkopf homolog 1 NM_012242.1 4.59
Kinetochore associated 2 NM_006101.1 3.51
Cell division cycle 2 AL524035 3.47
WNT4 NM_030761.1 -4.05
Fritz U91903.1 -4.83
Tumor necrosis factor-related protein NM_030945.1 -6.03
EGF-like-domain, multiple 6 NM_015507.2 -8.22
Transcription factors and nuclear proteins
Transcription factor AP-2 alpha BF343007 7.41
High mobility group AT-hook 1 NM_002131.1 5.58
Nuclear factor IB AI700518 4.49
Interferon-inducible protein p78 NM_002462.2 7.57
Cytoskeleton
Rabkinesin6 NM_005733.1 4.66
Stathmin-like 2 NM_007029.1 -5.32
Pregnancy specific beta-1-glycoprotein
Pregnancy specific beta-1-glycoprotein 7 NM_002783.1 -5.85
Pregnancy specific beta-1-glycoprotein 4 NM_002780.1 -17.82
Pregnancy specific beta-1-glycoprotein 1 NM_006905.1 -62.90
Uncharacterized genes
Hypothetical protein PRO02730 AL137654 10.56
Uncharacterized bone marrow protein NM_018454.1 5.06
Hypothetical protein FLJ10517 NM_018123.1 5.74
KIAA0101 gene product NM_014736.1 5.10
KIAA0008 gene product NM_014750.1 4.62
Doublecortin and CaM kinase-like 1 NM_004734.1 4.53
KIAA1547 gene product AW873621 3.96
Hypothetical protein DKFZp762E1312 NM_018410.1 4.54
Hypothetical protein FLJ10829 NM_018234.1 5.12
Clone HQ0310 PRO0310p1 NM_016359.1 4.38
Hypothetical protein DKFZp564H1916 AI186739 3.69
KIAA0042 gene product NM_014875.1 4.96
Hypothetical protein FLJ22009 NM_024745.1 4.11
Hypothetical protein FLJ23468 NM_024629.1 3.48
Hypothetical protein DKFZp564N1116 BF344237 4.03
Hypothetical protein FLJ10781 NM_018215.1 -3.68
Myomegalin AB042557.1 -4.97
Hypothetical protein DKFZp564B052 NM_030820.1 -5.46
KIAA0008 gene product AK002054.1 -16.44
MGC:3052 BC002449.1 -7.73
KIAA0865 gene product AI522028 -7.70
Miscellaneous
Matrix metalloproteinase 1 NM_002421.2 7.73
Carbonic anhydrase XII NM_001218.2 7.80
Topoisomerase II alpha AU159942 6.87
Step II splicing factor SLU7 AV733266 6.93
Monocyte chemotactic protein S69738.1 4.37
Ribonucleotide reductase M2 BE966236 4.59
Plasminogen activator, urokinase NM_002658.1 4.19
Cathepsin C NM_001814.1 4.34
Atrophin-1 interacting protein 1 NM_012301.1 -3.89
Monoamine oxidase A AA923354 -4.77
Type II iodothyronine deiodinase U53506.1 -2.80
Phosphatidylserine-binding protein NM_004657.1 -3.98
Scrapie responsive protein 1 NM_007281.1 -5.72
Natural killer cell transcript 4 NM_004221.1 -5.94
CD24 signal transducer L33930 -9.16
Elastase 2 NM_001972.1 -9.71
CD24 antigen AA761181 -19.19