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Table 5 Genome scan results (lod score ≥ 1.75) for lipids with and without medication correction by ethnicity: the HyperGEN study

From: An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study

    

Excluding medicated

Including medicated

Phenotype

Chromosome

cM (from p-ter)

Marker

No. of sibs

Lod score

No. of sibs

Lod score

       

Medication unadjusted

Medication adjusted

African Americans

        

   TC

6

53.81

GGAA15B08

1803

2.03

1889

2.18

2.66

 

21

36.77

ATA27F01

 

2.58

 

2.02

2.15

 

22

4.06

AFM217XF4

 

1.95

 

1.82

2.04

   HDL-C

9

75.88

GATA89A11

1797

1.44

1884

2.11

2.07

   LDL-C

2

132.58

GATA27A12

1786

1.46

1871

1.62

1.79

 

6

73.13

GATA11E02

 

2.22

 

2.36

1.81

 

21

57.77

GATA70B08

 

1.73

 

1.93

1.77

 

22

4.06

AFM217XF4

 

1.50

 

1.80

1.83

   TG

6

73.13

GATA11E02

1803

1.89

1888

2.18

2.06

 

9

44.28

GATA87E02

 

2.00

 

1.05

0.93

 

11

131.26

AFM157XH6

 

3.08

 

2.73

2.71

Whites

        

   TC

5

172.13

GATA7H10

1682

0.98

1924

0.73

1.92

 

14

91.62

GATA30A03

 

0.58

 

2.07

0.44

   HDL-C

1

274.53

GATA50F11

1678

1.92

1919

1.00

0.84

 

8

0.73

AFM143XD8

 

1.24

 

2.19

1.67

 

20

32.94

GATA81E09

 

1.72

 

1.02

1.76

   LDL-C

9

88.92

GATA81C04

1682

1.80

1858

0.43

0.59

  1. BMI = Body Mass Index; TC = Total Cholesterol; HDL-C = High Density Lipoprotein Cholesterol; LDL-C = Low Density Lipoprotein Cholesterol; TG = Triglycerides
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BMC Genomic Data

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