Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population

Table 1 Characteristics of the Odyssey and CLUE II subcohort study participants, Washington County, Maryland, 1989

Characteristic	Total N = 9,960	Odyssey N = 8,307	Subcohort N = 2,460	Age-adjusted OR (95%CI)*
Age (yrs)
Mean (SD)	53.2 (15.5)	55.6 (13.5)	45.7 (18.5)	1.04(1.04,1.05)^†
Min, Max	5, 95	28, 95	5, 94
Median (IQR)	54 (42, 65)	56 (45, 66)	46 (32, 61)
Gender
Male	3829 (38)	3111 (37)	1035 (42)	1.0
Female	6131 (62)	5196 (62)	1425 (58)	1.22(1.11,1.35)
Race
White	9831 (99)	8213 (99)	2415 (98)	1.0
Black	105 (1)	81 (1)	34 (1)	0.95(0.63,1.44)
Others	24	13	11	0.48(0.21,1.14)
BMI (kg/m ² )
< 25	4269 (43)	3392 (41)	1219 (50)	1.0
25 – 29.9	3758 (38)	3259 (39)	794 (32)	1.26(1.13,1.40)
=> 30	1921 (19)	1647 (20)	444 (18)	1.26(1.11,1.43)
Missing	12	9	3
Cigarette smoking
Never	5363 (54)	4474 (54)	1318 (53)	1.0
Former	2952 (30)	2545 (31)	669 (27)	0.90(0.81,1.01)
Current	1645 (17)	1288 (15)	473 (19)	0.91(0.80,1.04)
Education (years)
<12	2476 (25)	1994 (24)	680 (28)	1.0
=12	4555 (46)	3869 (47)	1038 (42)	1.65(1.47,1.86)
>12	2923 (29)	2439 (29)	741 (30)	1.50(1.32,1.71)
Missing	6	5	1
Blood pressure ^‡
Normal	2277 (23)	1719 (21)	705 (29)	1.0
Prehypertensive	4471(45)	3684 (44)	1159 (47)	0.95(0.84,1.07)
Hypertensive	3204 (32)	2896 (35)	595 (24)	0.95(0.83,1.09)
Missing	8	8	1
Cholesterol(mg/dl) with no treatment
< 200	4092 (44)	3223 (42)	1180 (50)	1.0
200 – 239	3472 (37)	2979 (38)	791 (33)	1.00(0.89,1.11)
>= 240	1773 (19)	1536 (20)	386 (16)	0.93(0.81,1.07)
Cholesterol(mg/dl) with treatment
< 200	119 (23)	108 (22)	21 (25)	1.0
200 – 239	223 (42)	205 (43)	33 (39)	1.19(0.65,2.15)
>= 240	184 (35)	168 (35)	30 (36)	1.05(0.57,1.93)

* age adjusted odds ratio of being an Odyssey cohort participant.
^† per year increment.
^‡ Normal blood pressure was defined as individuals with systolic pressure <120 mmHg and diastolic blood pressure of 80 mmHg and not on anti-hypertensive medication; Hypertension was defined as under anti-hypertensive medication or systolic pressure >140 mmHg or diastolic pressure of 90 mmHg. Individuals with systolic blood pressure between 120 and 140 mmHg and/or diastolic blood pressure between 80 mmHg and 90 mmHg were considered pre-hypertensive.

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