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Figure 3 | BMC Genetics

Figure 3

From: Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

Figure 3

Three-dimensional modeling of the first sushi domain of human SRPX2. A cartoon representation [65] is shown, highlighting the conserved Trp and Cys residues. The model reveals an additional putative disulfide bridge (Cys71-Cys87), atypical of the classical sushi (CCP) module fold. The hypervariable loop, with the sites of disease-causing mutation (Tyr72) and evolutionary change (Lys75) and the protrusion specific to SRPX, are indicated.

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BMC Genomic Data

ISSN: 2730-6844

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