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Table 1 Regions with MLS over 1.0 in either single- or two-locus linkage analysis

From: A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland

Chromosome Closest marker Location (cM) MLS (nominal p value)
    Single Two-Locus Conditional on 6p21
     Additive General
1q23 D1S1653 160 0.77 (0.0467) 0.43 (0.1240) 1.19 (0.0470)
2q34-36 D2S163 214 1.03 (0.0240) 0.99 (0.0327) 1.21 (0.0443)
3p21 D3S1581 64 0.51 (0.0935) 1.25 (0.0173) 1.25 (0.0407)
4q21 D4S1534 97 0.64 (0.0658) 0.29 (0.1876) 1.10 (0.0564)
6p21 D6S1575 58 4.67 (0.000004) NA NA NA NA
6q13 D6S1557 82 1.52 (0.0071) 0.06 (0.4040) 0.06 (0.5990)
6q16 D6S1709 109 1.68 (0.0048) 0.97 (0.0260) 0.97 (0.0770)
7p15 D7S516 36 0.49 (0.0987) 1.45 (0.0112) 1.45 (0.0277)
9p13 D9S1817 59 1.56 (0.0064) 3.09 (0.0002) 3.09 (0.0004)
12q14 D12S83 76 0.77 (0.0467) 0.29 (0.1876) 1.40 (0.0294)
13q32 D13S1298 74 0.43 (0.1167) 0.02 (0.4667) 1.23 (0.0428)
14q24 D14S986 77 1.15 (0.0177) 0.65 (0.0724) 1.53 (0.0241)
15q22 D15S1036 54 1.35 (0.0108) 1.65 (0.0064) 1.65 (0.0186)
17p12 D17S799 32 2.12 (0.0017) 1.65 (0.0064) 2.14 (0.0061)
18p11 D18S1163 22 1.83 (0.0033) 1.05 (0.0282) 2.47 (0.0029)
18p11 D18S453 42 1.18 (0.0164) 0.71 (0.0617) 1.30 (0.0366)
18q12 D18S457 55 1.06 (0.0222) 0.66 (0.0706) 1.17 (0.0487)
  1. MLS was estimated using TWOLOCARP [38], the p value for a single-locus MLS was calculated using "possible triangle restriction" [39], and for a two-locus MLS obtained by Simulation.
  2. NA: not available