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Table 1 Regions with MLS over 1.0 in either single- or two-locus linkage analysis

From: A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland

Chromosome

Closest marker

Location (cM)

MLS (nominal p value)

   

Single

Two-Locus Conditional on 6p21

    

Additive

General

1q23

D1S1653

160

0.77 (0.0467)

0.43 (0.1240)

1.19 (0.0470)

2q34-36

D2S163

214

1.03 (0.0240)

0.99 (0.0327)

1.21 (0.0443)

3p21

D3S1581

64

0.51 (0.0935)

1.25 (0.0173)

1.25 (0.0407)

4q21

D4S1534

97

0.64 (0.0658)

0.29 (0.1876)

1.10 (0.0564)

6p21

D6S1575

58

4.67 (0.000004)

NA NA

NA NA

6q13

D6S1557

82

1.52 (0.0071)

0.06 (0.4040)

0.06 (0.5990)

6q16

D6S1709

109

1.68 (0.0048)

0.97 (0.0260)

0.97 (0.0770)

7p15

D7S516

36

0.49 (0.0987)

1.45 (0.0112)

1.45 (0.0277)

9p13

D9S1817

59

1.56 (0.0064)

3.09 (0.0002)

3.09 (0.0004)

12q14

D12S83

76

0.77 (0.0467)

0.29 (0.1876)

1.40 (0.0294)

13q32

D13S1298

74

0.43 (0.1167)

0.02 (0.4667)

1.23 (0.0428)

14q24

D14S986

77

1.15 (0.0177)

0.65 (0.0724)

1.53 (0.0241)

15q22

D15S1036

54

1.35 (0.0108)

1.65 (0.0064)

1.65 (0.0186)

17p12

D17S799

32

2.12 (0.0017)

1.65 (0.0064)

2.14 (0.0061)

18p11

D18S1163

22

1.83 (0.0033)

1.05 (0.0282)

2.47 (0.0029)

18p11

D18S453

42

1.18 (0.0164)

0.71 (0.0617)

1.30 (0.0366)

18q12

D18S457

55

1.06 (0.0222)

0.66 (0.0706)

1.17 (0.0487)

  1. MLS was estimated using TWOLOCARP [38], the p value for a single-locus MLS was calculated using "possible triangle restriction" [39], and for a two-locus MLS obtained by Simulation.
  2. NA: not available