Table 3 Shift of residues with change of class according to R groups, conservation across species and PolyPhen predictions.
Gene | Protein residue* | Aa position | Change in class according to R group† | Residue conservation across 5 species‡ | PolyPhen prediction§ |
|---|---|---|---|---|---|
DRD1 | Thr [T]/Met [M] | 354 | No change | Invariant | Possibly damaging |
DRD3 | Gln [Q]/Arg [R] | 294 | Polar, uncharged/positively charged | Variable | Benign |
Leu [L]/Phe [F] | 341 | Nonpolar, aliphatic/aromatic | Invariant | Benign | |
DBH | Lys [K]/Asn [N] | 263 | Positively charged/polar, uncharged | Variable | Benign |
HTR1A | Lys [K]/Gln [Q] | 270 | Positively charged/polar, uncharged | Variable | Benign |
HTR1B | Ile [I]/Leu [L] | 53 | No change | Variable | Benign |
HTR1D | Ala [A]/Val [V] | 97 | No change | Invariant | Benign |
Glu [E]/Gly [G] | 263 | Negatively charged/Nonpolar, aliphatic | Variable | Benign | |
HTR2B | Thr [T]/Ile [I] | 88 | Polar, uncharged/nonpolar, aliphatic | Invariant | Probably damaging |
Ala [A]/Val [V] | 431 | No change | Variable | Predicted to be unknown | |
HTR3A | Thr [T]/Met [M] | 64 | No change | Variable | Possibly damaging |