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Table 4 Allele frequencies of the polymorphisms associated with melanogenesis, Hirschsprung disease, AMD, and the ability to taste PTC.

From: Prevalence of common disease-associated variants in Asian Indians

   Melanogenesis Hirschsprung AMD Ability to Taste PTC
Gene Name: SLC24A5 RET CFH LOC387715 TAS2R38 TAS2R38 TAS2R38
Nucleotide Change: g.13242G>A g.9349G>A g.37989T>C g.205G>T g.144G>C g.784C>T g.885A>G
  n G T C T C C G
Mother Tongue
Assamese 26 0.260 0.240 0.360 0.200 0.340 0.360 0.360
Bengali 27 0.293 0.207 0.276 0.397 0.310 0.310 0.310
Gujarati 181 0.208 0.271 0.333 0.375 0.313 0.313 0.313
Hindi 29 0.105 0.209 0.267 0.244 0.349 0.360 0.360
Kannada 24 0.268 0.232 0.304 0.464 0.196 0.250 0.250
Kashmiri 24 0.020 0.100 0.260 0.340 0.480 0.500 0.500
Konkani 43 0.058 0.250 0.385 0.269 0.308 0.308 0.308
Malayalam 25 0.259 0.259 0.222 0.500 0.259 0.296 0.296
Marathi 26 0.296 0.259 0.278 0.204 0.407 0.407 0.426
Marwari 25 0.041 0.273 0.265 0.334 0.384 0.398 0.406
Oriya 27 0.154 0.346 0.212 0.250 0.346 0.365 0.365
Parsi 25 0.100 0.300 0.300 0.380 0.280 0.280 0.300
Punjabi 28 0.052 0.293 0.431 0.414 0.328 0.310 0.328
Tamil 29 0.036 0.179 0.250 0.393 0.339 0.321 0.375
Telugu 28 0.000 0.188 0.167 0.354 0.417 0.417 0.417
FST   0 0.011 0.009 0 0.009 0.010 0.011
p-value   1 1 1 1 1 1 1
Gender
Female 237 0.110 0.232 0.268 0.348 0.331 0.338 0.342
Male 339 0.117 0.261 0.289 0.330 0.363 0.376 0.386
FST   0.049 0.020 0.037 0.042 0.020 0.007 0
p-value   0.825 0.887 0.847 0.837 0.887 0.933 1
Population
Cohort 576 0.114 0.249 0.280 0.338 0.350 0.360 0.368
Standard Error   0.028 0.015 0.018 0.024 0.018 0.017 0.017
HWE Constant   0.004 0.003 0.009 0.006 0.002 0.002 0.002
p-value   0.304 0.654 0.350 0.513 0.926 0.855 0.857
Welch modified t-test:        
Africa   4.21 × 10 -14     3.86 × 10 -4 3.24 × 10 -8 0.005
Europe   2.80 × 10 -4   4.20 × 10 -3 0.068 2.43 × 10 -6 5.78 × 10 -5 1.37 × 10 -4
Asia   7.18 × 10 -14   1.55 × 10 -8 0.018 0.055 7.97 × 10 -6 7.60 × 10 -6
Americas   0.024     0.006 1.92 × 10 -5 1.64 × 10 -5
Oceania       0.090 0.009 0.003
  1. P-values significant at <0.05 are shown in bold.