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Table 1 SNP and haplotype frequencies in the Mandenka sample.

From: Worldwide distribution of NAT2 diversity: Implications for NAT2 evolutionary history

Nucleotide Changea G191A C282T T341C C345Td C403Gc C481T G590A G609Tc C638Td A803G G838Ac G857A  
Amino Acid Change R64Q None I114T None L135V None R197Q E203D P213L K268R V280M G286E  
SNP Frequency 0.1031 0.3041 0.3608 0.0258 0.0206 0.3454 0.1701 0.0051 0.0103 0.5052 0.0051 0.0722  
Haplotypeb              Haplotype Frequency
NAT2*4 e G C T C C C G G C A G G 0.0928
NAT2*5A . . C . . T . . . . . . 0.0103
NAT2*5B . . C . . T . . . G . . 0.3300
NAT2*5C . . C . . . . . . G . . 0.0155
NAT2*6A . T . . . . A . . . . . 0.1289
NAT2*7B . T . . . . . . . . . A 0.0670
NAT2*12A . . . . . . . . . G . . 0.1289
NAT2*13 . T . . . . . . . . . . 0.0515
NAT2*14A A . . . . . . . . . . . 0.0876
NAT2*14B A T . . . . . . . . . . 0.0155
NAT2*12g c . . . . . . . T . G . . 0.0052
NAT2*6J d . T . . . . A . . . . A 0.0052
NAT2*12H c . . . . G . . . . G . . 0.0206
NAT2*5M d . . C . . T . . . G A . 0.0052
NAT2*6K d . T . . . . A . T . . . 0.0103
NAT2*6L d . T . T . . A . . . . . 0.0258
2N f              194
  1. a Polymorphic sites were numbered considering +1 as the A of the translation start codon in the cDNA sequence (GenBank CR407631)
  2. bNAT2 haplotypes were named in accordance with the consensus gene nomenclature of human NAT2 alleles [65]
  3. c These SNPs/haplotypes have been recently described in Patin et al. [10]
  4. d Newly reported SNPs/haplotypes in the present study
  5. eNAT2*4 is the reference allele that was shown to be the ancestral haplotype through outgroup comparisons with the chimpanzee and rhesus monkey sequences
  6. f Total number of chromosomes in the Mandenka sample