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Table 2 Allele and genotype frequencies of SNPs in COMT, DRD1, DRD2, DRD3 and DRD4 genes and their association status with diabetic CRI.

From: Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes

SNPs Allele frequency Genotype frequency Association
  DM (n = 225) CRI (n = 196) DM (n = 225) CRI (n = 196) Allele (df = 1) Genotype (df = 2)
COMT -287 G>A G = 0.63 G = 0.65 GG = 0.38 GG = 0.43 χ2 = 0.45; χ2 = 0.93;
  A = 0.37 A = 0.35 GA = 0.49 GA = 0.44 P = 0.50 P = 0.63
    AA = 0.13 AA = 0.13   
COMT 408 C>G C = 0.71 C = 0.69 CC = 0.51 CC = 0.47 χ2 = 0.61; χ2 = 0.98;
  G = 0.29 G = 0.31 CG = 0.39 CG = 0.44 P = 0.43 P = 0.61
    GG = 0.10 GG = 0.09   
COMT 472 G > A (Val158 Met) G = 0.53 G = 0.59 GG = 0.28 GG = 0.38 χ2 = 2.71; χ2 = 4.10;
  A = 0.47 A = 0.41 GA = 0.51 GA = 0.42 P = 0.10 P = 0.13
    AA = 0.21 AA = 0.20   
COMT 900 Ins/Del C Ins = 0.71 Ins = 0.69 Ins/Ins = 0.54 Ins/Ins = 0.46 χ2 = 0.59; χ2 = 5.83;
  Del = 0.29 Del = 0.31 Ins/Del = 0.34 Ins/Del = 0.46 P = 0.44 P = 0.054
    Del/Del = 0.12 Del/Del = 0.08   
DRD1 -48A>G A = 0.55 A = 0.82 AA = 0.33 AA = 0.34 χ2 = 0.33; χ2 = 1.83;
  G = 0.45 G = 0.18 AG = 0.44 AG = 0.46 P = 0.57 P = 0.401
    GG = 0.23 GG = 0.20   
DRD2 -141 ins/del C Ins = 0.74 Ins = 0.85 Ins/Ins = 0.57 Ins/Ins = 0.74 χ 2 = 12.11; χ 2 = 11.3;
  Del = 0.26 Del = 0.15 Ins/Del = 0.35 Ins/Del = 0.23 P < 0.001 a P = 0.004 a
    Del/Del = 0.08 Del/Del = 0.03   
DRD2 G>A G = 0.77 G = 0.66 GG = 0.61 GG = 0.45 χ 2 = 7.94; χ 2 = 7.83;
  A = 0.23 A = 0.34 GA = 0.31 GA = 0.42 P = 0.005 P = 0.02
    AA = 0.08 AA = 0.13   
DRD2 T>C T = 0.74 T = 0.69 TT = 0.55 TT = 0.48 χ2 = 2.30; χ2 = 2.18;
  C = 0.26 C = 0.31 TC = 0.37 TC = 0.41 P = 0.13 P = 0.335
    CC = 0.08 CC = 0.11   
DRD3 Ser9Gly C = 0.64 C = 0.59 CC = 0.43 CC = 0.35 χ2 = 2.03; χ2 = 2.8
  G = 0.36 G = 0.41 CG = 0.42 CG = 0.48 P = 0.15 P = 0.25
    GG = 0.15 GG = 0.17   
DRD4 -120 bp Deletion Ins = 0.68 Ins = 0.73 Ins/Ins = 0.48 Ins/Ins = 0.53 χ2 = 1.77; χ2 = 1.72;
  Del = 0.32 Del = 0.27 Ins/Del = 0.42 Ins/Del = 0.39 P = 0.18 P = 0.42
    Del/Del = 0.105 Del/Del = 0.08   
DRD4 -521 C>T C = 0.40 C = 0.45 CC = 0.18 CC = 0.22 χ2 = 1.25; χ2 = 1.15;
  T = 0.60 T = 0.55 CT = 0.44 CT = 0.45 P = 0.26 P = 0.56
    TT = 0.38 TT = 0.33   
DRD4 48 bp VNTR 371 = 0.06 371 = 0.08 371/371 = 0.005 371/371 = 0.02 χ2 = 7.25; χ2 = 10.6;
  419 = 0.02 419 = 0.02 467/371 = 0.10 467/371 = 0.10 P = 0.30 (df = 6) P = 0.156 (df = 7)
  467 = 0.86 467 = 0.80 467/419 = 0.02 467/419 = 0.04   
  563 = 0.03 563 = 0.04 467/467 = 0.78 467/467 = 0.68   
  611 = 0.01 611 = 0.01 467/563 = 0.02 467/563 = 0.03   
  647 = 0.02 647 = 0.04 467/611 = 0.02 467/611 = 0.03   
    467/647 = 0.02 467/647 = 0.067   
    563/563 = 0.014 419/647 = 0.007   
  1. aSignificant after Bonferroni's correction α = 0.0042