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Table 4 SNP haplotypes in DRD2 gene

From: Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes

aHaplotype

DM (398) n*;f**

CRI (380) n*;f**

χ2

P

O.R (95% CI)

111

217 (0.545)

173 (0.046)

4.97

0.03

0.69 (0.49–0.96)

211

56 (0.14)

40 (0.105)

1.65

0.20

0.73 (0.44–1.19)

112

18 (0.045)

39 (0.102)

6.94

0.01

2.37 (1.23–4.60)

212

14 (0.035)

00 (0.00)

6.23

0.01

0.09 (0.01–0.74)

121

11 (0.027)

38 (0.1)

b 13.51

<<0.01

4.08 (1.83–9.11)

221

01 (0.002)

01 (0.002)

0.43

0.51

1.08 (0.08–17.32)

122

41 (0.103)

80 (0.21)

b 12.94

<<0.01

2.33 (1.46–3.73)

222

39 (0.098)

09 (0.023)

b 13.50

<<0.01

0.23 (0.10–0.54)

  1. aOrder of SNPs in the DRD2 haplotypes: -141 ins/del C – G>A (Intron 1) – T>C (Intron 7)
  2. bSignificant after Bonferroni's correction α = 0.0063
  3. *n = total number
  4. **f = frequency