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Table 2 Association analyses of CAPN1 polymorphisms with carcass traits (CW and MS) among Korean native cattle

From: A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle

    

Genotype

  

Trait

Polymorphism

Position

Amino acid change

C/C

C/R

R/R

P

P cor.

    

N(LSMEAN ± SE)

N(LSMEAN ± SE)

N(LSMEAN ± SE)

  

CW

c.579G>A

Exon5

K193K

187(309.56 ± 2.58)

177(311.93 ± 2.57)

53(314.91 ± 4.99)

0.33

NS

 

c.630A>G

Exon6

T210T

174(312.17 ± 2.61)

180(311.14 ± 2.53)

67(310.88 ± 4.20)

0.16

NS

 

c.760-24T>C

Intron6

.

210(312.93 ± 2.24)

161(306.26 ± 2.72)

43(319.27 ± 4.92)

0.11

NS

 

c.843+330A>G

Intron7

.

224(312.42 ± 2.21)

156(306.68 ± 2.65)

31(323.82 ± 6.18)

0.69

NS

 

c.1199G>A

Exon11

R400Q

417(311.43 ± 1.50)

3(294.47 ± 19.76)

.

0.46

NS

 

c.1588G>A

Exon14

V530I

289(311.78 ± 1.93)

111(309.62 ± 3.27)

15(311.41 ± 9.12)

0.84

NS

 

c.1611+104C>T

Intron14

.

227(311.32 ± 2.26)

155(311.06 ± 2.74)

33(313.20 ± 5.98)

0.88

NS

 

c.1869+235C>G

Intron18

.

128(313.33 ± 3.15)

189(308.92 ± 2.50)

102(312.55 ± 3.23)

0.73

NS

 

c.2151*479C>T

3'UTR

.

342(311.37 ± 1.78)

65(304.72 ± 4.80)

5(321.32 ± 16.27)

0.49

NS

 

c.2151*765A>G

3'UTR

.

307(310.08 ± 2.01)

96(310.63 ± 4.15)

12(311.52 ± 11.10)

0.23

NS

 

c.2151*832G>A

3'UTR

.

335(311.67 ± 1.75)

75(309.30 ± 4.14)

4(315.85 ± 19.01)

0.84

NS

 

c.2151*845A>G

3'UTR

.

293(308.97 ± 2.07)

112(312.82 ± 3.75)

12(317.88 ± 10.33)

0.11

NS

 

Block2_ht2

.

.

300(310.77 ± 1.86)

95(314.78 ± 3.50)

15(300.73 ± 8.72)

0.85

NS

 

Block2_ht3

.

.

335(310.25 ± 1.80)

72(316.69 ± 4.68)

3(303.60 ± 20.41)

0.46

NS

MS

c.579G>A

Exon5

K193K

187(2.10 ± 0.10)

177(2.39 ± 0.10)

53(2.00 ± 0.19)

0.85

NS

 

c.630A>G

Exon6

T210T

174(2.19 ± 0.10)

180(2.29 ± 0.10)

67(2.09 ± 0.17)

0.64

NS

 

c.760-24T>C

Intron6

.

210(2.18 ± 0.09)

161(2.26 ± 0.11)

43(2.16 ± 0.20)

0.69

NS

 

c.843+330A>G

Intron7

.

224(2.18 ± 0.09)

156(2.21 ± 0.11)

31(2.16 ± 0.25)

0.78

NS

 

c.1199G>A

Exon11

R400Q

417(2.21 ± 0.06)

3(1.77 ± 0.79)

.

0.47

NS

 

c.1588G>A

Exon14

V530I

289(2.21 ± 0.08)

111(2.24 ± 0.13)

15(2.12 ± 0.37)

0.60

NS

 

c.1611+104C>T

Intron14

.

227(2.19 ± 0.09)

155(2.17 ± 0.11)

33(2.56 ± 0.24)

0.22

NS

 

c.1869+235C>G

Intron18

.

128(2.30 ± 0.13)

189(2.23 ± 0.10)

102(2.12 ± 0.13)

0.09

NS

 

c.2151*479C>T

3'UTR

.

342(2.34 ± 0.07)

65(1.56 ± 0.19)

5(0.94 ± 0.65)

0.0007

0.02

 

c.2151*765A>G

3'UTR

.

307(2.19 ± 0.08)

96(2.33 ± 0.17)

12(2.67 ± 0.45)

0.08

NS

 

c.2151*832G>A

3'UTR

.

335(2.20 ± 0.07)

75(2.31 ± 0.17)

4(1.10 ± 0.76)

0.13

NS

 

c.2151*845A>G

3'UTR

.

293(2.15 ± 0.08)

112(2.42 ± 0.15)

12(2.77 ± 0.41)

0.06

NS

 

Block2_ht2

.

.

300(2.11 ± 0.07)

95(2.56 ± 0.14)

15(2.20 ± 0.35)

0.28

NS

 

Block2_ht3

.

.

335(2.14 ± 0.07)

72(2.54 ± 0.19)

3(2.28 ± 0.82)

0.21

NS

  1. Genotype and haplotype distributions and P-values controlling for sire and age at slaughter as covariates are shown.
  2. C/C, C/R, and R/R represent the common allele, and heterozygotes and homozygotes for the rare allele, respectively.
  3. N(LSMEAN ± SE): Number of animals (least square mean of values ± standard errors).
  4. Pcor.represents the simple corrected P-value (Bonferroni correction).
  5. Significant associations are shown in boldface. NS: not significant