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Table 3 Scg5 promoter polymorphisms in C57BL/6J, C57BL/6J-hg/hg, BALB/cByJ, C3H/HeJ, DBA/2J and CAST/EiJ strains

From: Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice

Strain

Scg5 exp.

-2475 (A/G)

-2445 (A/C)

-1540 (A/G)

-1373 (A/G)

-1095 (G/C)

-904 (G/T)

-794 (G/A)

-659 (A/G)

-432 (C/T)

del-432

-306 (A/C)

C57BL/6J

LOW

AA

AA

AA

GG

GG

GG

GG

AA

CC

+

AA

C57BL/6J-hg/hg

LOW

AA

AA

AA

GG

GG

GG

GG

AA

CC

+

AA

BALB/cByJ

HIGH

AA

AA

AA

AA

GG

GG

AA

GG

del

del

N/A

C3H/HeJ

HIGH

AA

AA

AA

AA

GG

GG

AA

GG

del

del

N/A

DBA/2J

HIGH

AA

AA

AA

AA

GG

GG

AA

GG

del

del

N/A

CAST/EiJ

HIGH

GG

CC

GG

AA

CC

TT

AA

GG

TT

+

CC

  1. SNPs are numbered based on position upstream from transcription start site as defined by RefSeq NM_009162,. SNPs with genotypes in bold italics segregate low expressers and high expressers. +, deletion not present in these strains; del, deletion is present in these strains; N/A, genotypes for -306 were not determined for strains with deletion due to the forward primer sequence overlapping the deletion.