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Table 8 Detected interactions in genders before and after SEM -LCA.

From: Analysis of heterogeneity and epistasis in physiological mixed populations by combined structural equation modelling and latent class analysis

  Significance level
  0.0017 2.5 E-9
1 Detected in both gender and LCA 245 56.3% 196 45.1%
2 Not detected in either gender or LCA 61 14.0% 68 15.6%
3 Detected in both LCA but not in any gender 97 22.3% 133 30.6%
4 Detected only in gender 2 0.5% 2 0.5%
5 Detected in one LCA and in gender 23 5.3% 23 5.3%
6 Detected in one LCA but not in gender 7 1.6% 13 3.0%
Full agreement between both gender and LCA (1+2) 306 70.3% 264 60.7%
Detected in one or both LCA but not in gender (3+6) 104 23.9% 146 33.6%
Actual number of possible interactions 378    
SNPs with no interactions (equivalent for both scenarios): TCF1   HNF4α-6
  1. Number of interactions between the 30 SNPs included in this study at two Bonferoni corrected significance levels corresponding to a 30 SNP study (0.0017) and to a future 20-million-SNP scenario (2.5 E-9). Percentage indicates the fraction of possible number of interactions for 30 SNPs (i.e., 435)