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Table 1 Genes with synthetic slow growth or synthetic lethal interactions with tra1SRR 3413

From: Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes

GENE 1 Orf SSL2 GO3 Location, component4 phenotype5 stress6 #7
MCK1 YNL307C SL 1, 3 cytoplasm, nucleus   X 28
CDC73 YLR418C s 1, 3, 10 Cdc73/Paf complex, nucleus T, R X 159
CSE2 YNR010W S 1, 3, 10 mediator complex R X 19
HTZ1 YOL012C S 1, 3, 10 nucleus    186
LEO1 YOR123C s 1, 3, 10 Cdc73/Paf complex, nucleus T   39
RAD52 YML032C s 1, 3, 10 nucleus   X 196
SPT8 YLR055C s 1, 3, 10 SAGA complex, nucleus    62
SRB2 YHR041C s 1, 3, 10 Srb-mediator complex T, E   34
SWR1 YDR334W s 1, 3, 10 SWR1 complex, nucleus R   112
VPS71 YML041C s 1, 3, 10, 9 SWR1 complex, nucleus E   97
VPS72 YDR485C s 1, 3, 10, 9 SWR1 complex, nucleus E   87
KAR3 YPR141C s 1, 3, 7 microtubule, spindle pole body E   131
UBI4 YLL039C s 1, 3, 8, 9 cytoplasm   X 7
UBP15 YMR304W s 1, 3, 8, 9 cytoplasm    0
SWC3 YAL011W s 1, 3, 9, 10 SWR1 complex, nucleus, mitochondrion    85
DOA1 YKL213C s 1, 9, 8 cytoplasm, nucleus   X 26
TOR1 YJR066W S 1,2,3,4,5,6,7,8,9,10 cellular membranes R X 27
CKB2 YOR039W s 1,2,3,4,5,7,8,9,10 protein kinase CK2, CURI complex   X 14
SNF1 YDR477W s 1,3,4,5,6,7,8,9,10 cytoplasm, nucleus, nuclear evelope, mitochondrion, vacuole R X 18
SNF4 YGL115W S 1,3,4,5,6,7,8,9,10 cytoplasm, nucleus, nuclear envelope, PM    7
CNB1 YKL190W s 1,3,4,5,7,9,10 calcineurin complex   X 48
EOS1 YNL080C S 1,3,4,7 ER membrane   X 4
SIS2 YKR072C s 1,3,5,10 cytoplasm, nucleus   X 10
NUM1 YDR150W s 1,3,7,9 cell cortex, cellular bud tip, mitochondrion    57
SWI4 YER111C s 1, 3, 7, 10 nucleus CW   69
UBP6 YFR010W S 1,3,8,9,10 proteosome   X 28
MSC1 YML128C s 1,3,9,6 ER, mitochondrion R   14
ARP6 YLR085C s 10, 1, 2 SWR1 complex, cytoplasm R   149
CAF40 YNL288W s 2, 10 CCR4-NOT complex R   8
NST1 YNL091W s 2, 10 cytoplasm   X 2
PUB1 YNL016W s 2, 10 cytoplasm, nucleus, hnRNP complex   X 5
PIH1 YHR034C s 2, 3, 8, 10 cytoplasm, nucleus, snRNP complex    2
HMT1 YBR034C s 2, 4 10 nucleus    4
PML39 YML107C SL 2, 4, 10 nuclear pore, ribosome    4
HCR1 YLR192C s 2, 8 translation IF3 complex T X 5
PPQ1 YPL179W S 2, 8 cytoplasm    0
TMA23 YMR269W s 2, 8 nucleolus, ribosome    5
RRP6 YOR001W SL 2, 8, 10 nuclear exosome (RNase complex)    16
SKY1 YMR216C s 2,3,4,8,10 cytoplasm    5
STP1 YDR463W s 2,4,7,8,10 nucleus    2
KNS1 YLL019C SL 3    X 0
BIM1 YER016W s 3, 1, 7 cytoplasm, microtubule, kinetochore, spindle pole body    282
NBP2 YDR162C s 3, 7 cytoplasm, nucleus CW, R X 49
PRB1 YEL060C s 3, 8, 9 vacuole   X 3
SEL1 YML013W s 3, 8, 9 ubiquitin ligase complex, ER, mitochondrion    3
TPS2 YDR074W s 3,5,7,8,10 mitochondrion   X 4
ITR1 YDR497C s 4, 5, 7, 9 plasma membrane   X 9
NEW1 YPL226W s 4, 5, 9, 8 cytoplasm, mitochondrion    8
AQR2 YBR043C s 4, 7 plasma membrane    1
GTR1 YML121W s 4, 9 cytoplasm, endosome, nucleus, vacuole T, E, R   5
VAM10 YOR068C SL 4, 9 vacuolar membrane    11
SER1 YOR184W s 5 cytoplasm    1
SER2 YGR208W s 5 cytoplasm, nucleus    5
GCR2 YNL199C SL 5, 10, 3 nucleus E   30
ARO1 YDR127W SL 5, 6 cytoplasm E   0
ARO2 YGL148W SL 5, 6 cytoplasm    1
ETR1 YBR026C s 5, 6 mitochondrion    0
LIP2 YLR239C s 5, 6 mitochondrion    7
LIP5 YOR196C S 5, 6 mitochondrion    2
OAR1 YKL055C s 5, 6 mitochondrion    0
ERG3 YLR056W s 5, 9 ER    19
MDM34 YGL219C S 6 mitochondrial outer membrane E, R   10
KGD2 YDR148C S 6, 5 mitochondrion    0
MDM10 YAL010C s 6, 9 Mdm10/Mdm12/Mmm1 complex, mitochondrial outer membrane T, E   11
BEM1 YBR200W S 7, 3, 1 bud neck E   33
BEM4 YPL161C s 7, 3, 1 cytoplasm, nucleus T, E X 29
Smi1 YGR229C s 7, 3, 1 bud tip, nucleus T, E, CW, R   111
ROM2 YLR371W SL 7, 3, 9 bud tip   X 16
CSF1 YLR087C s 7, 5, 6 mitochondrion CW   24
ECM30 YLR436C s 7, 9 cytoplasm CW   1
KRE1 YNL322C s 7, 9 cell wall    64
VIP1 YLR410W S 7, 9 cytoplasm    15
TPM1 YNL079C S 7,9,3 actin cable E, CW, R   21
RPS27B YHR021C S 8 ribosome T   1
RPN4 YDL020C S 8, 10, 1, 3 nucleus, proteasome T, E X 242
YDJ1 YNL064C S 8, 9, 6 cytosol, microsome R X 27
CCZ1 YBR131W s 9 late endosome, membrane E, R X 6
MON1 YGL124C s 9 cytosol, vacuolar membrane    12
VAM3 YOR106W s 9 vacuolar membrane R   9
VAM7 YGL212W s 9 vacuolar membrane T, E, CW, R   8
PIB2 YGL023C s 9, 1, 7 late endosome, mitochondrion R   0
GSG1 YDR108W s 9, 3 TRAPP complex   X 11
  YDR049W s 9, 3, 8 cytoplasm, mitochondrion E, R   
MEH1 YKR007W S 9, 4, 5 cytosol, vacuolar membrane   X 2
PMR1 YGL167C s 9, 4, 7 Golgi membrane E   41
AUT7 YBL078C s 9, 5 autophagic vacuole, cytosol   X 2
CCW12 YLR110C s 9, 7 cell wall CW   13
COG5 YNL051W S 9, 7 Golgi    14
COG6 YNL041C S 9, 7 Golgi    17
COG7 YGL005C S 9, 7 Golgi    12
COG8 YML071C S 9, 7 Golgi    17
DID2 YKR035W s 9, 7 cytoplasm, late endosome    2
GYP1 YOR070C S 9, 7 Golgi, mitochondrion R   48
MNN10 YDR245W s 9, 7 α-1,6-mannosyltransferase complex E, R, CW   19
MON2 YNL297C s 9, 7 cytosol, endosome R   40
RIC1 YLR039C S 9, 7 Golgi, nucleus E   159
RUD3 YOR216C s 9, 7 Golgi    26
SEC22 YLR268W s 9, 7 ER, Golgi CW   44
TLG2 YOL018C s 9, 7 early endosome, trans Golgi R   12
VPS1 YKR001C S 9, 7 cytoplasm, membrane fraction    28
VPS17 YOR132W s 9, 7 endosome, retromer complex    11
VPS38 YLR360W s 9, 7 Vps34 complex R   12
VPS41 YDR080W s 9, 7 HOPS complex, vacuolar membrane, endosome R   7
VPS53 YJL029C SL 9, 7 GARP complex, Golgi, cytoplasm T, R   10
YPT6 YLR262C s 9, 7 Golgi E, R   181
YPT7 YML001W s 9, 7 vacuole, mitochondrion T, R   6
  YLR111W s 9, 7   CW   0
GET1 YGL020C S 9, 8 GET complex, ER, mitochondrion R X 284
SSE1 YPL106C SL 9, 8 cytoplasm T   15
BTS1 YPL069C S 9,5,6 mitochondrion CW   16
UBP3 YER151C s 9,7,10,1,3 cytoplasm R   32
  YDL180W s   vacuole    0
  YEL033W s    T   0
  YOR235W s      0
  1. 1 Genes are placed according to related GO terms with relevant groupings separated by lines.
  2. 2 Phenotype of double mutants. SL, synthetic lethal; S, severe slow growth; s, slow growth (in SC media at 33.5°C). For those underlined the phenotype is most easily detected on YPD at 30C as the single mutant shows reduced growth on SC media
  3. 3 Gene ontology: (1) DNA replication/repair and chromosome stability, (2) RNA processing, (3) cell cycle/microtubule, (4) general transport, (5) metabolism, (6) mitochondria, (7) polarity/cell wall, (8) protein/ribosome biosynthesis, (9) secretion/protein trafficking, (10) transcription, (11) unknown
  4. 4 Cellular compartments and/or components as indicated in the Saccharomyces Genome Database
  5. 5 Relevant phenotypes of single mutants as described in the Saccharomyces Genome Database. E, sensitivity to ethanol; CW, sensitivity to calcofluor white; T, shortened telomeres; R, sensitivity to rapamycin
  6. 6 Annotated in the Saccharomyces Genome Database as involved in stress response or autophagy
  7. 7 Number of previously identified SSL interactions in the Saccharomyces Genome Database