BMC Genomic Data

Table 2 TDR and FDR under Model 2

From: Application of two machine learning algorithms to genetic association studies in the presence of covariates

	RF		MARS
Approach	TDR	FDR	TDR	FDR
1. Include Z	+	-	+	+
2. Stratify by Z	-	+	-	+
3. Residualize by Z	-	+	+	+
4. Ignore Z	+	-	+	-

Correlation between X₁ and Z is varied as shown in Figures 3 and 4: "+" indicates reasonable TDR (> 80 for RF and > 70% for MARS) or low FDR (< 20% for RF and < 10% for MARS) for all levels of correlation; and "-" indicates decreasing TDR or increasing FDR as correlation increases.

Back to article page

ISSN: 2730-6844

Contact us

General enquiries: journalsubmissions@springernature.com