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Table 2 TDR and FDR under Model 2

From: Application of two machine learning algorithms to genetic association studies in the presence of covariates

  RF MARS
Approach TDR FDR TDR FDR
1. Include Z + - + +
2. Stratify by Z - + - +
3. Residualize by Z - + + +
4. Ignore Z + - + -
  1. Correlation between X1 and Z is varied as shown in Figures 3 and 4: "+" indicates reasonable TDR (> 80 for RF and > 70% for MARS) or low FDR (< 20% for RF and < 10% for MARS) for all levels of correlation; and "-" indicates decreasing TDR or increasing FDR as correlation increases.