Table 3 TDR for detecting genotype effects in the presence of a continuous covariate

MODEL 1: ADDITIVE

β/σ = γ/σ = 0.5

MODEL 2: ADDITIVE WITH CONFOUNDING

β/σ = γ/σ = 0.5

MODEL 3: ADDITIVE WITH EFFECT MEDIATION

β/σ = 0.5, γ/σ = 2

MODEL 4: INTERACTION

β/σ = γ/σ = ζ/σ = 0.5

MODEL 5: INTERACTION, NO MAIN EFFECTS

ζ/σ = 0.5

MODEL 6: CONDITIONAL ASSOCIATION

γ/σ = ζ/σ = 0.5