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Table 6 MARS results of the analysis of ACTG data with HDL-c levels as trait and SNPs from ApoCIII, ApoE, EL and HL genes and race/ethnicity as predictors

From: Application of two machine learning algorithms to genetic association studies in the presence of covariates

  Include* Ignore* Residualize* White
(n = 317)
Stratify* Black
(n = 92)
Hispanic
(n = 103)
ApoC-III       
-482C/T (rs2854117) 4 - 1 1 - -
-455T/C (rs2854116) - 3 2 3 - -
intron 1 (466)G/C (rs2070669) - - - - - -
Gly34Gly C/T (rs4520) - - - - - -
exon 4 SstI 4348(5) C/G (rs5128) - - - - - -
ApoE       
Arg112Cys T/C (rs429358) - - 1 - - -
Arg158Cys T/C (rs7412) 3 1 - 2 - -
EL       
rs12970066, 5 - - 4 1 -
Asn396Ser, 4 - - 1 1 -
rs3829632 (-1309A/G) - - - - - -
HL       
rs2070895 3 1 - 2 - -
rs12595191 - - - - - -
rs690, 4 2 - 1 - -
rs6084 2 - 1 - 1 -
Race/ethnicity 1 NA NA NA NA NA
  1. " * " indicates the approach to handling the race/ethnicity covariate;
  2. "NA" indicates that the predictor was not included in the analysis;
  3. and "-" indicates that the predictor was not selected in the final MARS model.