Figure 3
From: Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6
Pedigrees. Pedigrees of four of the half-sib families (sired by stallion 1–4) used in this study. Phenotype information along with genotype data on one genetic marker (PMEL17ex11) is shown for all individuals. Unaffected horses are indicated by open symbols, half filled symbols indicate horses affected with cysts, solid symbols indicate horses affected with MCOA and unexamined horses are indicated by symbols enclosing a question mark. We selected the SNP PMEL17ex11 to represent the near perfect correlation between phenotype and genotype of the three markers in our interval that show complete linkage with the MCOA locus. The only discrepancy (marked in red) is a healthy dam with a heterozygous genotype. However, since she has produced two MCOA affected offspring, this dam is most likely a case where the position and/or size of the cysts make them extremely difficult to detect. NG: Not Genotyped (as DNA was not available).