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Table 3 Estimated haplotype frequencies of two SNPs (C23356T and A33065G), estimated log odds ratios and their standard errors for all common haplotypes formed by identified SNPs

From: A systematic search for SNPs/haplotypes associated with disease phenotypes using a haplotype-based stepwise procedure

Haplotype Control Freq. Case Freq. Coef. Odds Ratio 95% CI Z-Score P-value
  Discovery Cohort (363 patients)
TG 0.33 0.21   1.00 (reference)   
CA 0.39 0.42 0.42 1.52 (1.05, 2.21) 2.21 0.027
CG 0.21 0.23 0.56 1.75 (1.12, 2.72) 2.46 0.014
TA 0.07 0.15 1.21 3.36 (1.77, 6.37) 3.71 0.000
  Validation Cohort (209 patients)
TG 0.34 0.20   1.00 (reference)   
CA 0.40 0.49 0.68 1.98 (1.19, 3.27) 2.65 0.008
CG 0.18 0.23 0.75 2.11 (0.99, 4.50) 1.94 0.053
TA 0.09 0.09 0.63 1.87 (0.67, 5.23) 1.20 0.230