Table 3 Estimated haplotype frequencies of two SNPs (C23356T and A33065G), estimated log odds ratios and their standard errors for all common haplotypes formed by identified SNPs
Haplotype | Control Freq. | Case Freq. | Coef. | Odds Ratio | 95% CI | Z-Score | P-value |
|---|---|---|---|---|---|---|---|
| Â | Discovery Cohort (363 patients) | ||||||
TG | 0.33 | 0.21 | Â | 1.00 | (reference) | Â | Â |
CA | 0.39 | 0.42 | 0.42 | 1.52 | (1.05, 2.21) | 2.21 | 0.027 |
CG | 0.21 | 0.23 | 0.56 | 1.75 | (1.12, 2.72) | 2.46 | 0.014 |
TA | 0.07 | 0.15 | 1.21 | 3.36 | (1.77, 6.37) | 3.71 | 0.000 |
| Â | Validation Cohort (209 patients) | ||||||
TG | 0.34 | 0.20 | Â | 1.00 | (reference) | Â | Â |
CA | 0.40 | 0.49 | 0.68 | 1.98 | (1.19, 3.27) | 2.65 | 0.008 |
CG | 0.18 | 0.23 | 0.75 | 2.11 | (0.99, 4.50) | 1.94 | 0.053 |
TA | 0.09 | 0.09 | 0.63 | 1.87 | (0.67, 5.23) | 1.20 | 0.230 |