Does dietary folic acid supplementation in mouse NTD models affect neural tube development or gamete preference at fertilization?

Table 1 Association between parental FA supplementation and incidence of NTDs

Mutant, diet	% Affected (n)	Sample size
Apob^{tm1Unc/tm1Unc} - exencephaly
2 ppm	96 (26)	27
10 ppm	96 (26)	27
Vangl2^Lp/Lp - craniorachischisis
2 ppm	100 (15)	15
10 ppm	100 (11)	11
Vangl2^Lp/Lp – looped tail
2 ppm	98 (40)	41
10 ppm	97 (31)	32

Fisher’s exact test was used to determine whether FA-supplementation affected the incidence of NTDs in mutant homozygotes or heterozygotes. The number of affected embryos is shown in parentheses. No significant differences were detected.

ISSN: 2730-6844