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Table 1 Observed statistical power of QTL additive and epistatic effect detection and effect estimation from simulation with architecture 1

From: Mapping epistatic quantitative trait loci

QTL Chr:cM Eff Pw11 Pw12 Pw21 Pw22 Pw31 Pw32 EffE PosE Cov Width
1 1:47 1.41 100.0 98.3 100.0 100.0 100.0 100.0 1.32 (.02) 44.09 (.60) 100 9.30
2 1:80 1.41 99.0 99.0 100.0 100.0 100.0 100.0 1.47 (.13) 79.96 (.25) 91.6 3.99
3 2:49 0.00 11.3 0.0 87.3 11.7 100.0 100.0 0.24 (.07) 45.24 (.59) 92.6 10.20
4 3:22 1.41 100.0 100.0 100.0 100.0 100.0 100.0 1.41 (.22) 21.99 (.69) 90.0 5.50
5 3:78 0.00 10.3 0.3 88.3 88.3 88.3 88.3 0.02 (.02) 76.93 (.33) 99.3 9.96
6 6:5 0.00 13.3 0.0 11.7 11.7 100.0 100.0 -0.04 (.06) 7.50 (1.1) 92.6 12.74
7 7:70 1.41 100.0 100.0 100.0 100.0 100.0 100.0 1.41 (.03) 69.91 (.31) 100.0 5.07
8 9:63 0.00 12.7 0.0 88.3 88.3 88.3 88.3 0.07 (.04) 63.25 (1.1) 100.0 7.93
FPR 0.124 0.000 0.030 0.024 0.038 0.037
#QTL (std 1.18) 5.10 3.99 6.97 6.15 8.08 8.06
EPIS Q1:Q2 Eff Pw11 Pw12 Pw21 Pw22 Pw31 Pw32 EffE
1 1:2 1.77 90.3 89.3 91.7 96.0 96.0 96.3 1.90 (.38)
2 2:4 1.77 94.7 91.7 92.3 92.3 92.3 92.3 1.68 (.49)
3 2:7 -1.77 95.7 93.3 93.3 93.3 93.3 93.3 -1.64 (.44)
4 3:6 1.77 0.0 0.0 11.7 11.7 100.0 100.0 1.79 (.08)
5 4:5 -1.77 0.7 0.0 88.0 88.0 88.0 88.0 -1.35 (.50)
6 4:8 1.77 3.0 0.0 88.3 77.7 77.7 77.7 1.42 (.76)
7 5:7 1.77 1.0 0.0 88.0 88.0 88.0 88.0 1.36 (.51)
8 7:8 -1.77 3.0 0.0 88.3 88.3 88.3 88.3 -1.74 (.63)
FPR 0.316 0.001 0.160 0.031 0.053 0.036
  1. The upper panel shows the results for QTL additive effects and the lower panel shows the results for QTL epistatistic effects. Total heritability (h2) is 0.8 with the additive component 0.5 and the epistatic component 0.3. Chr:cM is the QTL chromosome and cM position. Q1:Q2 is the interacting QTL pair. Eff is the simulated effect. Pw11 is the observed statistical power from Stage 1 forward search, Pw12 is that from Stage 1 after optimization and elimination; Pw21 is from Stage 2 forward search, Pw22 is from Stage 2 after the final step of backward elimination of QTL; Pw31 and Pw32 are from the similar steps in Stage 3. EffE is the average effect size estimate and PosE is the average position estimate. (Standard deviations are in parentheses.) Cov is the percent coverage for LOD-1 support interval and Width is the average width in cM of the LOD-1 support interval. FPR is false positive rate. #QTL row records average number of QTL found.