Skip to main content

Table 2 Single-SNP association analysis for DN at the 16q22.1-16q22.2 regions under the additive model a

From: Identified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population

SNP Minor (major) allele MAF (Cases) MAF (Controls) Gene Location Crude OR (95% CI) p-valueb Adjusted OR (95% CI) p-valuec
rs4985526 T (C) 0.26 0.33 ST3GAL2 intron 0.71 (0.55-0.93) 1.26E-02 0.72 (0.55-0.95) 1.79E-02
rs11647932 T (C) 0.24 0.14 ST3GAL2 intron 1.84 (1.36-2.50) 6.39E-05 1.82 (1.34-2.48) 1.37E-04
rs8062183 A (G) 0.35 0.45 ST3GAL2 near-gene-5 0.68 (0.53-0.87) 2.19E-03 0.69 (0.53-0.88) 3.55E-03
rs2303792 G (A) 0.35 0.44 COG4 intron 0.68 (0.53-0.88) 2.54E-03 0.69 (0.53-0.89) 4.05E-03
rs8052125 T (G) 0.35 0.44 COG4 intron 0.67 (0.52-0.86) 1.68E-03 0.68 (0.52-0.87) 2.79E-03
rs2288491 T (C) 0.35 0.44 SF3B3 intron 0.68 (0.53-0.88) 2.62E-03 0.69 (0.53-0.89) 3.91E-03
rs4985534 T (C) 0.24 0.31 SF3B3 intron 0.69 (0.53-0.90) 6.91E-03 0.69 (0.52-0.91) 8.23E-03
rs11645214 G (A) 0.49 0.33 SF3B3 3' UTR 1.92 (1.49-2.48) 3.07E-07 1.94 (1.49-2.51) 6.25E-07
rs6499323 G (A) 0.47 0.34 IL34 intron 1.77 (1.38-2.28) 7.24E-06 1.81 (1.40-2.35) 7.10E-06
rs7197333 C (T) 0.16 0.21 IL34 intron 0.71 (0.52-0.97) 2.86E-02 0.69 (0.51-0.95) 2.20E-02
rs1006985 C (T) 0.44 0.50 IL34 intron 0.76 (0.60-0.97) 2.85E-02 0.75 (0.58-0.96) 2.18E-02
  1. MAF: minor allele frequency.
  2. aSignificant SNPs (p-value <10-4) identified from single-SNP association analysis, along with the other 8 SNPs identified from haplotype association analysis, are presented.
  3. bp-value from Chi-square test (Cochran-Armitage trend test).
  4. cp-value from logistic regression under an additive model (an ordinal genotype model: 0, 1 and 2 of a minor allele) after adjustment of subject's sex, age, BMI, and durations of diabetes.