Identified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population

Table 2 Single-SNP association analysis for DN at the 16q22.1-16q22.2 regions under the additive model ^a

SNP	Minor (major) allele	MAF (Cases)	MAF (Controls)	Gene	Location	Crude OR (95% CI)	p-value^b	Adjusted OR (95% CI)	p-value^c
rs4985526	T (C)	0.26	0.33	ST3GAL2	intron	0.71 (0.55-0.93)	1.26E-02	0.72 (0.55-0.95)	1.79E-02
rs11647932	T (C)	0.24	0.14	ST3GAL2	intron	1.84 (1.36-2.50)	6.39E-05	1.82 (1.34-2.48)	1.37E-04
rs8062183	A (G)	0.35	0.45	ST3GAL2	near-gene-5	0.68 (0.53-0.87)	2.19E-03	0.69 (0.53-0.88)	3.55E-03
rs2303792	G (A)	0.35	0.44	COG4	intron	0.68 (0.53-0.88)	2.54E-03	0.69 (0.53-0.89)	4.05E-03
rs8052125	T (G)	0.35	0.44	COG4	intron	0.67 (0.52-0.86)	1.68E-03	0.68 (0.52-0.87)	2.79E-03
rs2288491	T (C)	0.35	0.44	SF3B3	intron	0.68 (0.53-0.88)	2.62E-03	0.69 (0.53-0.89)	3.91E-03
rs4985534	T (C)	0.24	0.31	SF3B3	intron	0.69 (0.53-0.90)	6.91E-03	0.69 (0.52-0.91)	8.23E-03
rs11645214	G (A)	0.49	0.33	SF3B3	3' UTR	1.92 (1.49-2.48)	3.07E-07	1.94 (1.49-2.51)	6.25E-07
rs6499323	G (A)	0.47	0.34	IL34	intron	1.77 (1.38-2.28)	7.24E-06	1.81 (1.40-2.35)	7.10E-06
rs7197333	C (T)	0.16	0.21	IL34	intron	0.71 (0.52-0.97)	2.86E-02	0.69 (0.51-0.95)	2.20E-02
rs1006985	C (T)	0.44	0.50	IL34	intron	0.76 (0.60-0.97)	2.85E-02	0.75 (0.58-0.96)	2.18E-02

MAF: minor allele frequency.
^aSignificant SNPs (p-value <10^-4) identified from single-SNP association analysis, along with the other 8 SNPs identified from haplotype association analysis, are presented.
^bp-value from Chi-square test (Cochran-Armitage trend test).
^cp-value from logistic regression under an additive model (an ordinal genotype model: 0, 1 and 2 of a minor allele) after adjustment of subject's sex, age, BMI, and durations of diabetes.

ISSN: 2730-6844