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Table 3 Haplotypic association tests for DN at the 16q22.1-16q22.2 regions a

From: Identified single-nucleotide polymorphisms and haplotypes at 16q22.1 increase diabetic nephropathy risk in Han Chinese population

Haplotypesb SNPs H-freq (Cases) H-freq (Controls) Crude OR (95% CI) p-valuec Adjusted OR (95% CI) p-valued
Window size of 3-SNP       
H1 (C-T-G) rs4985526-rs11647932-rs8062183 0.24 0.14 1.86 (1.72-2.01) 7.36E-05 1.84 (1.70-1.99) 1.10E-04
H2 (T-G-A) rs11647932-rs8062183-rs2303792 0.24 0.14 1.85 (1.71-2.00) 7.18E-05 1.84 (1.70-1.99) 1.07E-04
H3 (C-C-G) rs2288491-rs4985534-rs11645214 0.49 0.33 1.92 (1.82-2.02) 5.40E-07 1.93 (1.83-2.03) 6.25E-07
H4 (C-G-G) rs4985534-rs11645214-rs6499323 0.47 0.33 1.86 (1.76-1.96) 2.08E-06 1.90 (1.80-2.01) 1.48E-06
H5 (G-G-T) rs11645214-rs6499323-rs7197333 0.47 0.33 1.86 (1.76-1.96) 2.08E-06 1.90 (1.80-2.01) 1.48E-06
H6 (G-T-T) rs6499323-rs7197333-rs1006985 0.39 0.27 1.73 (1.62-1.84) 4.42E-05 1.85 (1.74-1.97) 8.93E-06
Window size of 4-SNP       
H7 (T-G-A-G) rs11647932-rs8062183-rs2303792-rs8052125 0.24 0.14 1.85 (1.71-2.00) 8.22E-05 1.85 (1.71-2.00) 8.04E-05
H8 (G-C-C-G) rs8052125-rs2288491-rs4985534-rs11645214 0.48 0.33 1.91 (1.81-2.01) 6.99E-07 1.92 (1.82-2.02) 6.56E-07
H9 (C-C-G-G) rs2288491-rs4985534-rs11645214-rs6499323 0.47 0.33 1.86 (1.76-1.96) 2.08E-06 1.87 (1.77-1.97) 1.76E-06
H10 (C-G-G-T) rs4985534-rs11645214-rs6499323-rs7197333 0.47 0.33 1.86 (1.76-1.96) 2.08E-06 1.87 (1.77-1.97) 1.76E-06
H11 (G-G-T-T) rs11645214-rs6499323-rs7197333-rs1006985 0.39 0.27 1.74 (1.63-1.86) 4.63E-05 1.76 (1.65-1.88) 3.16E-05
Window size of 5-SNP       
H12 (A-G-C-C-G) rs2303792-rs8052125-rs2288491-rs4985534-rs11645214 0.48 0.33 1.90 (1.80-2.00) 9.62E-07 1.91 (1.81-2.01) 1.15E-06
H13 (G-C-C-G-G) rs8052125-rs2288491-rs4985534-rs11645214-rs6499323 0.47 0.33 1.86 (1.76-1.96) 2.08E-06 1.90 (1.80-2.01) 1.48E-06
H14 (C-C-G-G-T) rs2288491-rs4985534-rs11645214-rs6499323-rs7197333 0.47 0.33 1.86 (1.76-1.96) 2.08E-06 1.90 (1.80-2.01) 1.48E-06
H15 (C-G-G-T-T) rs4985534-rs11645214-rs6499323-rs7197333-rs1006985 0.39 0.27 1.74 (1.63-1.86) 4.72E-05 1.85 (1.74-1.97) 9.85E-06
  1. H-freq: haplotype frequency.
  2. aOnly crude p-value <10-4 was presented.
  3. bA haplotype with a frequency of >0.05 was included in the analysis.
  4. cp-value from logistic regression.
  5. dp-value from logistic regression after adjustment of subject's sex, age, BMI, and durations of diabetes.