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Table 2 Characteristics of the four GHRL / GHSR polymorphisms in six studies in breast cancer (BC), colorectal cancer (CRC), esophageal cancer (EC) and Non-Hodgkin’s Lymphoma (NHL)

From: Associations between ghrelin and ghrelin receptor polymorphisms and cancer in Caucasian populations: a meta-analysis

    Number of     
First author (year) Ethnicity Cancer type Cases Controls Total Power (α = 0.05, OR = 1.5) MAF HWE
rs696217 Leu72Met GHRL exon 3
Dossus [11] Europe Breast 1,324 2,360 3,684 99.9 0.08 0.81
Feigelson [12] USA Breast 639 649 1,288 94.8 0.08 0.76
Wagner [14] Europe Breast 395 456 851 82.8 0.08 0.84
Campa [23] Europe CRC 678 600 1,278 94.6 0.07 0.05
Doecke [10] Australia EC 260 1,352 1,612 83.9 0.08 0.05
Skibola [13] USA NHL 305 684 989 82.7 0.08 0.59
rs4684677 Gln90Leu GHRL exon 4
Dossus [11] Europe Breast 1,311 2,339 3,650 99.9 0.06 0.78
Feigelson [12] USA Breast 634 647 1,281 94.7 0.05 0.14
Campa [23] Europe CRC 683 600 1,283 94.6 0.07 0.83
Doecke [10] Australia EC 260 1,352 1,612 83.9 0.06 0.02
rs2075356 3056 T > C GHRL intron 3/in2c ghrelin 3′UTR
Dossus [11] Europe Breast 634 1,734 2,368 99.1 0.09 0.93
Feigelson [12] USA Breast 640 652 1,292 94.9 0.10 0.72
Campa [23] Europe CRC 667 583 1,250 94.1 0.08 0.05
GHSR rs572169 Gly57Gly GHSR exon 1
Dossus [11] Europe Breast 1,327 2,368 3,695 99.9 0.27 0.06
Wagner [14] Europe Breast 402 458 860 83.2 0.26 0.004
Campa [23] Europe CRC 649 588 1,237 93.9 0.28 0.77
  1. Minor allele frequency (MAF); Hardy-Weinberg Equilibrium (HWE). UTR = untranslated region.