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Table 3 Summary odds ratios (OR) of associations between four ghrelin/GHSR gene polymorphisms with cancer using four genetic models (homozygous, dominant, recessive and co-dominant) in all studies analysed and in breast cancer studies alone

From: Associations between ghrelin and ghrelin receptor polymorphisms and cancer in Caucasian populations: a meta-analysis

   Homozygous Recessive Dominant Co-dominant
  N OR (95% CI) P value Phet I2 OR (95% CI) P value Phet I2 OR (95% CI) P value Phet I2 OR (95% CI) P value Phet I2
rs696217 6 0.63 (0.36-1.11) 0.11 0.82 0 0.61 (0.35-1.08) 0.09 0.77 0 0.98 (0.87-1.11) 0.79 0.17 36 0.96 (0.86-1.07) 0.49 0.37 8
rs696217a 3 0.82 (0.41-1.62) 0.57 0.87 0 0.83 (0.42-1.65) 0.60 0.87 0 0.90 (0.78-1.05) 0.19 0.99 0 0.91 (0.79-1.04) 0.18 0.97 0
rs4684677 3 1.98 (0.92-4.26) 0.08 0.46 0 1.97 (0.92-4.24) 0.08 0.46 0 1.00 (0.86-1.16) 0.98* 0.28 22 1.02 (0.89-1.18) 0.75 0.28 23
rs4684677a 2 2.40 (0.98-5.86) 0.06 0.29 10 2.38 (0.97-5.81) 0.06 0.28 13 1.08 (0.90-1.30) 0.39 0.37 0 1.11 (0.94-1.32) 0.23 0.50 0
rs2075356 3 0.78 (0.41-1.47) 0.45 0.95 0 0.78 (0.41-1.46) 0.43 0.96 0 1.02(0.88-1.20) 0.76 0.58 0 1.02 (0.88-1.18) 0.79 0.56 0
rs2075356a 2 0.73 (0.33-1.62) 0.43 0.97 0 0.73 (0.33-1.62) 0.43 1.00 0 0.99 (0.83-1.19) 0.92 0.45 0 0.99 (0.84-1.18) 0.93 0.38 0
rs572169 3 1.42 (0.95-2.13) 0.08 0.04R 68 1.43 (0.95-2.14) 0.08 0.03R 70 1.05 (0.94-1.16) 0.40 0.82 0 1.08 (1.00-1.18) 0.05 0.34 7
rs572169a 2 1.69 (0.84-3.41) 0.14 0.02R 81 1.70 (0.84-3.44) 0.14 0.02R 82 1.05 (0.93-1.18) 0.46 0.53 0 1.10 (1.00-1.21) 0.05 0.17 46
  1. abreast cancer only; N: number of studies; *N = 4; OR: odds ratio; CI: confidence interval; Phet: P value for heterogeneity; the meta-analysis was conducted using the fixed-effects model unless otherwise stated; Rrandom-effects model (Bold indicates increased risk).
  2. I2 values as measure of heterogeneity are considered low (<44%), moderate (45-74%) or high (>75%).