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Table 3 Summary odds ratios (OR) of associations between four ghrelin/GHSR gene polymorphisms with cancer using four genetic models (homozygous, dominant, recessive and co-dominant) in all studies analysed and in breast cancer studies alone

From: Associations between ghrelin and ghrelin receptor polymorphisms and cancer in Caucasian populations: a meta-analysis

  

Homozygous

Recessive

Dominant

Co-dominant

 

N

OR (95% CI) P value

Phet

I2

OR (95% CI) P value

Phet

I2

OR (95% CI) P value

Phet

I2

OR (95% CI) P value

Phet

I2

rs696217

6

0.63 (0.36-1.11) 0.11

0.82

0

0.61 (0.35-1.08) 0.09

0.77

0

0.98 (0.87-1.11) 0.79

0.17

36

0.96 (0.86-1.07) 0.49

0.37

8

rs696217a

3

0.82 (0.41-1.62) 0.57

0.87

0

0.83 (0.42-1.65) 0.60

0.87

0

0.90 (0.78-1.05) 0.19

0.99

0

0.91 (0.79-1.04) 0.18

0.97

0

rs4684677

3

1.98 (0.92-4.26) 0.08

0.46

0

1.97 (0.92-4.24) 0.08

0.46

0

1.00 (0.86-1.16) 0.98*

0.28

22

1.02 (0.89-1.18) 0.75

0.28

23

rs4684677a

2

2.40 (0.98-5.86) 0.06

0.29

10

2.38 (0.97-5.81) 0.06

0.28

13

1.08 (0.90-1.30) 0.39

0.37

0

1.11 (0.94-1.32) 0.23

0.50

0

rs2075356

3

0.78 (0.41-1.47) 0.45

0.95

0

0.78 (0.41-1.46) 0.43

0.96

0

1.02(0.88-1.20) 0.76

0.58

0

1.02 (0.88-1.18) 0.79

0.56

0

rs2075356a

2

0.73 (0.33-1.62) 0.43

0.97

0

0.73 (0.33-1.62) 0.43

1.00

0

0.99 (0.83-1.19) 0.92

0.45

0

0.99 (0.84-1.18) 0.93

0.38

0

rs572169

3

1.42 (0.95-2.13) 0.08

0.04R

68

1.43 (0.95-2.14) 0.08

0.03R

70

1.05 (0.94-1.16) 0.40

0.82

0

1.08 (1.00-1.18) 0.05

0.34

7

rs572169a

2

1.69 (0.84-3.41) 0.14

0.02R

81

1.70 (0.84-3.44) 0.14

0.02R

82

1.05 (0.93-1.18) 0.46

0.53

0

1.10 (1.00-1.21) 0.05

0.17

46

  1. abreast cancer only; N: number of studies; *N = 4; OR: odds ratio; CI: confidence interval; Phet: P value for heterogeneity; the meta-analysis was conducted using the fixed-effects model unless otherwise stated; Rrandom-effects model (Bold indicates increased risk).
  2. I2 values as measure of heterogeneity are considered low (<44%), moderate (45-74%) or high (>75%).