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Table 2 Allele frequency profiles for SLC6A3 , ANKK1/DRD2 , and CYP2A6 polymorphism genotypes for current and former smokers

From: Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population

Allele/Genotype

All a

Current smoker

Former smoker

Number

%

Number

%

Number

%

SLC6A3

      

 10r

172

89.6

136

90.7

36

85.7

 9r

9

4.7

7

4.7

2

4.8

 7r

8

4.2

6

4.0

2

4.8

 6r

3

1.6

1

0.7

2

4.8

 10r/10r

77

80.2

61

81.3

16

76.2

 10r/9r

9

9.4

7

9.3

2

9.5

 10r/7r

6

6.3

6

8.0

0

0.0

 10r/6r

3

3.1

1

1.3

2

9.5

 7r/7r

1

1.0

0

0.0

1

4.8

HWEbP-value

0.96

0.37

0.31

ANKK1/DRD2

      

 A2

112

58.3

91

60.7

21

50.0

 A1

80

41.7

59

39.3

21

50.0

 A2/A2

33

34.4

27

36.0

6

28.6

 A2/A1

46

47.9

37

49.3

9

42.9

 A1/A1

17

17.7

11

14.7

6

28.6

HWEbP-value

0.89

0.77

0.51

CYP2A6

      

 *1

164

85.4

126

84.0

38

90.5

 *4

28

14.6

24

16.0

4

9.5

 *1/*1

73

76.0

55

73.3

18

85.7

 *1/*4

18

18.8

16

21.3

2

9.5

 *4/*4

5

5.2

4

5.3

1

4.8

HWEbP-value

0.02

0.07

0.04

  1. aNumber of alleles or genotypes for combined current and former smokers; and bHardy-Weinberg equilibrium of genotype distributions of each polymorphism was tested for current smokers, former smokers, and the whole cohort.