Skip to main content

Table 2 Allele frequency profiles for SLC6A3 , ANKK1/DRD2 , and CYP2A6 polymorphism genotypes for current and former smokers

From: Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population

Allele/Genotype All a Current smoker Former smoker
Number % Number % Number %
SLC6A3       
 10r 172 89.6 136 90.7 36 85.7
 9r 9 4.7 7 4.7 2 4.8
 7r 8 4.2 6 4.0 2 4.8
 6r 3 1.6 1 0.7 2 4.8
 10r/10r 77 80.2 61 81.3 16 76.2
 10r/9r 9 9.4 7 9.3 2 9.5
 10r/7r 6 6.3 6 8.0 0 0.0
 10r/6r 3 3.1 1 1.3 2 9.5
 7r/7r 1 1.0 0 0.0 1 4.8
HWEbP-value 0.96 0.37 0.31
ANKK1/DRD2       
 A2 112 58.3 91 60.7 21 50.0
 A1 80 41.7 59 39.3 21 50.0
 A2/A2 33 34.4 27 36.0 6 28.6
 A2/A1 46 47.9 37 49.3 9 42.9
 A1/A1 17 17.7 11 14.7 6 28.6
HWEbP-value 0.89 0.77 0.51
CYP2A6       
 *1 164 85.4 126 84.0 38 90.5
 *4 28 14.6 24 16.0 4 9.5
 *1/*1 73 76.0 55 73.3 18 85.7
 *1/*4 18 18.8 16 21.3 2 9.5
 *4/*4 5 5.2 4 5.3 1 4.8
HWEbP-value 0.02 0.07 0.04
  1. aNumber of alleles or genotypes for combined current and former smokers; and bHardy-Weinberg equilibrium of genotype distributions of each polymorphism was tested for current smokers, former smokers, and the whole cohort.