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Table 3 Profiles of participants were categorized by smoking status for SLC6A3 , ANKK1/DRD2 , and CYP2A6 polymorphism genotypes

From: Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population

(A) Current smoker

Genotypes

Number

Age

Age at which

Duration of smoking

Male

Female

participant began smoking

SLC6A3 10r/10r

57

4

31.51 ± 11.72

19.33 ± 2.01

11.82 ± 11.12

10r/# or #/#

12

2

36.93 ± 13.36

19.36 ± 1.84

16.43 ± 13.12

  

P-value

0.119

0.855

0.361

ANKK1/DRD2 A2/A2

25

2

34.05 ± 13.89

19.67 ± 2.15

13.98 ± 13.99

A2/A1 or A1/A1

44

4

31.65 ± 11.09

19.15 ± 1.87

11.95 ± 10.05

  

P-value

0.435

0.523

0.965

CYP2A6 *1/*1

50

5

32.58 ± 11.79

19.27 ± 2.09

13.05 ± 11.90

*1/*4 or *4/*4

20

1

31.90 ± 13.16

19.14 ± 2.31

11.24 ± 10.73

  

P-value

0.716

0.846

0.654

(B) Former smoker

Genotypes

Number

Age

  

Male

Female

   

SLC6A3 10r/10r

15

1

48.69 ± 10.98

  

10r/# or #/#

4

1

51.2 ± 6.98

  
  

P-value

0.901

  

ANKK1/DRD2 A2/A2

6

0

50.667 ± 8.824

  

A2/A1 or A1/A1

13

2

48.733 ± 10.760

  
  

P-value

0.697

  

CYP2A6 *1/*1

16

2

49.44 ± 10.56

  

*1/*4 or *4/*4

3

0

48.33 ± 8.02

  
  

P-value

0.840

  
  1. #DAT alleles with less than 10 repeats. P-value; the Mann–Whitney U test was conducted for participant age and smoking history of each genotype.
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BMC Genomic Data

ISSN: 2730-6844

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