Figure 1

Heterozygosity meta-analysis by study. 1.57% decreased risk of death for every standard deviation increase in heterozygosity. This is determined using an inverse variance weighted fixed effect model. Significance of P = 0.03 is determined using Stouffer's method to combine Z-scores due to bias in inverse variance weighted fixed effect model. There are 46,716 individuals, including a total of 15,234 deaths. EA = European Ancestry; AA = African Ancestry; AGES = Age, Gene/Environment Susceptibility cohort; ARIC = Atherosclerosis Risk In Communities cohort; CHS = Cardiovascular Health Study; FHS = Framingham Heart Study; HealthABC = HealthABC cohort; HRS = Health and Retirement Study; INCHINTI = InCHIANTI cohort; LBC1921 = 1921 Lothian Birth Cohort; LBC1936 = 1936 Lothian Birth Cohort; MAP = Rush Memory and Aging Project cohort; ROS = Religious Orders Study; Rotterdam = Rotterdam Study; SHIP = Study of Health In Pomerania cohort; SE = Standard Error; HR = Hazard Ratio; CI = Confidence Interval; W = Weight; N = Number.