Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart disease risk

Table 2 Adjusted Odds Ratios and 95% Confidence Intervals for CHD risk by different genotypes of the uric acid related SNPs in CHD cases and controls

SNPs gene location	Genotypes	Cases n (%)	Controls n (%)	Age- and sex- adjusted	P value	Multivariate model 1 ^a	P value	Multivariate model 2 ^b	P value	Multivariate model 3 ^c	P value
rs11722228	CC	564(50.2)	586(52.7)	1.00	-	1.00	-	1.00	-	1.00	-
SLC2A9	CT	472(42.0)	449(40.3)	1.09(0.92-1.30)	0.319	1.14(0.95-1.37)	0.175	1.08(0.89-1.31)	0.445	1.06(0.85-1.32)	0.611
4p16.1	TT	87(7.8)	78(7.0)	1.16(0.83-1.60)	0.388	1.19(0.84-1.69)	0.322	1.05(0.73-1.51)	0.801	1.27(0.84-1.93)	0.262
	CT+TT	559(49.8)	527(47.3)	1.10(0.93-1.30)	0.268	1.15(0.96-1.37)	0.135	1.07(0.89-1.29)	0.452	1.09(0.88-1.35)	0.433
rs4148152	AA	533(47.4)	463(42.0)	1.00	-	1.00	-	1.00	-	1.00	-
ABCG2	AG	479(42.6)	530(48.1)	0.78(0.66-0.93)	0.006	0.80(0.66-0.97)	0.019	0.85(0.70-1.03)	0.088	0.92(0.74-1.16)	0.483
4q22	GG	112(10.0)	109(9.9)	0.89(0.67-1.20)	0.445	0.81(0.59-1.11)	0.192	0.81(0.58-1.12)	0.200	0.77(0.53-1.13)	0.182
	AG+GG	591(52.6)	639(58.0)	0.80(0.68-0.95)	0.010	0.80(0.67-0.96)	0.015	0.84(0.70-1.01)	0.062	0.89(0.72-1.11)	0.306

^a, adjusted for age (continuous), sex (male, female), smoking (yes/no), drinking (yes/no) and family history of CHD (yes/no).
^b, adjusted for the same set of variables in model 1 plus BMI (continuous).
^c, adjusted for the same set of variables in model 2 plus total cholesterol (continuous), triglyceride (continuous), and the history of hypertension and diabetes (yes/no).

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