Table 2 Summary of results for analysis of associations between VDR variants and melanoma risk (total and stratified analysis)
Variant | Genetic model | Total | PCC | HCC | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | Q/df | P a | I 2 | OR (95% CI) | Q/df | P a | I 2 | OR (95% CI) | Q/df | P a | I 2 | ||
Bsm1 | Bb vs. bb | 0.85 (0.76-0.95) | 2.46/5 | 0.782 | 0% | 0.90 (0.78-1.04) | 0.44/3 | 0.933 | 0% | 0.75 (0.60-0.92) | NA | NA | NA |
BB vs. bb | 0.83 (0.68-1.00) | 6.92/5 | 0.227 | 28% | 0.81 (0.59-1.13) | 6.55/3 | 0.088 | 54% | 0.78 (0.59-1.04) | NA | NA | NA | |
BB + Bb vs. bb | 0.85 (0.76-0.94) | 3.79/5 | 0.580 | 0% | 0.89 (0.78-1.02) | 1.98/3 | 0.577 | 0% | 0.75 (0.62-0.92) | NA | NA | NA | |
Cdx2 | GA vs. GG | 0.95 (0.81-1.13) | 0.49/2 | 0.784 | 0% | 0.92 (0.76-1.12) | 0.03/1 | 0.867 | 0% | NA | NA | NA | NA |
AA vs.GG | 1.00 (0.68-1.46) | 1.71/2 | 0.426 | 0% | 1.10 (0.73-1.67) | 0.20/1 | 0.656 | 0% | NA | NA | NA | NA | |
AA + GA vs. GG | 0.96 (0.82-1.12) | 0.15/2 | 0.929 | 0% | 0.96 (0.79-1.14) | 0.07/1 | 0.786 | 0% | NA | NA | NA | NA | |
EcoRV | GA vs. AA | 1.09 (0.93-1.27) | 11. 4/7 | 0.122 | 39% | 1.12 (0.93-1.36) | 9.66/5 | 0.085 | 48% | 1.00 (0.70-1.41) | 1.36/1 | 0.244 | 26% |
GG vs. AA | 1.09 (0.90-1.33) | 10.32/7 | 0.182 | 32% | 1.00 (0.85-1.18) | 4.99/5 | 0.417 | 0% | 1.63 (0.79-3.36) | 2.58/1 | 0.108 | 61% | |
GA + GG vs. AA | 1.09 (0.94-1.26) | 10.91/7 | 0.143 | 36% | 1.09 (0.92-1.29) | 8.70/5 | 0.122 | 43% | 1.15 (0.74-1.78) | 2.19/1 | 0.139 | 54% | |
Fok1 | Ff vs. FF | 1.18 (1.06-1.30) | 5.65/8 | 0.686 | 0% | 1.14 (0.99-1.31) | 2.21/4 | 0.697 | 0% | 1.27 (1.08-1.49) | 1.62/2 | 0.444 | 0% |
ff vs. FF | 1.19 (1.01-1.41) | 10.25/8 | 0.248 | 22% | 1.20 (0.92-1.58) | 7.05/4 | 0.133 | 43% | 1.12 (0.85-1.49) | 2.39/2 | 0.303 | 16% | |
ff + Ff vs. FF | 1.18 (1.07-1.29) | 7.21/8 | 0.515 | 0% | 1.15 (1.01-1.31) | 3.98/4 | 0.409 | 0% | 1.24 (1.04-1.49) | 2.5/2 | 0.287 | 20% | |
Taq1 | Tt vs. TT | 1.03 (0.83-1.27) | 20.47/6 | 0.002 | 71% | 1.11 (0.86-1.42) | 8.06/3 | 0.045 | 63% | 0.92 (0.64-1.34) | 7.66/2 | 0.022 | 74% |
tt vs. TT | 0.97 (0.75-1.27) | 16.07/6 | 0.013 | 63% | 1.11 (0.78-1.57) | 7.98/3 | 0.046 | 62% | 0.79 (0.57-1.11) | 3.26/2 | 0.196 | 39% | |
tt + Tt vs. TT | 1.03 (0.82-1.28) | 24.76/6 | < 0.001 | 76% | 1.12 (0.86-1.46) | 10.20/3 | 0.017 | 71% | 0.91 (0.63-1.31) | 8.23/2 | 0.016 | 76% | |
Apa1 | Aa vs. AA | 1.14 (0.94-1.39) | 0.46/2 | 0.795 | 0% | 1.14 (0.94-1.39) | 0.46/2 | 0.795 | 0% | NA | NA | NA | NA |
aa vs. AA | 1.07 (0.75-1.54) | 3.96/2 | 0.138 | 50% | 1.07 (0.75-1.54) | 3.96/2 | 0.138 | 50% | NA | NA | NA | NA | |
aa + Aa vs. AA | 1.12 (0.93-1.34) | 1.68/2 | 0.431 | 0% | 1.12 (0.93-1.34) | 1.68/2 | 0.431 | 0% | NA | NA | NA | NA | |