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Table 1 Characteristic of the studies included in this meta-analysis

From: Association of TNF-alpha, IL-6 and IL-1beta gene polymorphisms with polycystic ovary syndrome: a meta-analysis

Study name

Year

Country

Ethnicity

Age, years, mean ± SD

Sample size

PCOS diagnostic criteria

Genotyping method

NOS score

Genotype (case/control)

P HWE b

Cases

Controls

Cases

Controls

11

12

22

TNF-alpha (−308 G/A)

              

Milner et al. [14]

1999

Australia

Caucasian

NA

NA

84

108

NIH criteria

PCR-SSCP

4

59/63

23/42

2/3

0.194

Mao et al. [15]

2000

China

Asian

28.0 ± 0.5

31.1 ± 1.1

118

54

NIH criteria

PCR-RFLP

6

88/37

29/13

1/4

0.089

Vural et al. [22]

2010

Turkey

Caucasian

25 (17–39)a

27 (18–39)a

97

95

Rotterdam criteria

PCR-RFLP

8

78/77

16/15

3/3

0.055

Zhang et al. [16]

2010

China

Asian

29.0 ± 1.5

30.0 ± 1.5

78

40

Rotterdam criteria

Microarray

7

72/36

6/4

0/0

0.739

Deepika et al. [17]

2013

India

Asian

NA

NA

283

306

Rotterdam criteria

ARMS PCR

6

10/10

270/293

3/3

<0.05

Wen et al. [18]

2013

China

Asian

26.86 ± 4.5

27.3 ± 3.71

103

59

Rotterdam criteria

PCR-RFLP

8

89/52

14/7

0/0

0.628

Grech et al. [19]

2014

Greece

Caucasian

22.5 ± 3.2

NA

39

140

Rotterdam criteria

PCR-RFLP

5

33/125

6/14

0/1

0.394

IL-6 (−174 G/C)

              

Walch et al. [20]

2004

Austria

Caucasian

28 (20–39)a

NA

62

94

Rotterdam criteria

Pyrosequencing

6

24/43

30/35

8/16

0.068

Erdogan et al. [21]

2009

Turkey

Caucasian

24.07 ± 1.32

25.01 ± 2.05

88

119

Rotterdam criteria

PCR-RFLP

8

57/32

26/75

5/12

<0.05

Vural et al. [22]

2010

Turkey

Caucasian

25 (17–39)a

27 (18–39)a

97

95

Rotterdam criteria

PCR-RFLP

8

59/46

34/42

4/7

0.536

Tumu et al. [23]

2013

India

Asian

26.35 ± 3.88

30.00 ± 5.17

104

156

Rotterdam criteria

Pyrosequencing

6

69/77

31/73

4/6

<0.05

IL-1beta (−511 C/T)

              

Kolbus et al. [24]

2007

Austria

Caucasian

27.9 ± 5.0

28.8 ± 5.9

105

102

Rotterdam criteria

Pyrosequencing

7

43/40

47/48

15/14

0.947

Yang et al. [25]

2009

China

Asian

NA

NA

118

86

Rotterdam criteria

PCR-RFLP

5

30/34

56/26

32/26

<0.05

Mu et al. [26]

2010

China

Asian

26.91 ± 4.02

31.14 ± 4.22

200

177

Rotterdam criteria

PCR-RFLP

6

64/26

76/87

60/64

0.684

Xia et al. [7]

2013

China

Asian

29.75 ± 3.62

28.93 ± 3.91

59

56

Rotterdam criteria

PCR-RFLP

6

13/18

21/31

25/7

0.257

  1. For TNF-alpha (−308 G/A), 11 = GG, 12 = GA, 22 = AA; For IL-6 (−174 G/C), 11 = GG, 12 = GC, 22 = CC; For IL-1beta (−511 C/T), 11 = CC, 12 = CT, 22 = TT.
  2. NA, not available; HWE, Hardy–Weinberg equilibrium; PCR-RFLP, polymerase chain reaction–restriction fragment length polymorphism; SSCP, single-strand conformational polymorphism; ARMS, amplification refractory mutation system; NOS, Newcastle-Ottawa Scale; avalues are given as median (range); b p value for HWE in controls.