Study name | Year | Country | Ethnicity | Age, years, mean ± SD | Sample size | PCOS diagnostic criteria | Genotyping method | NOS score | Genotype (case/control) | P HWE b | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | Cases | Controls | 11 | 12 | 22 | ||||||||
TNF-alpha (−308 G/A) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milner et al. [14] | 1999 | Australia | Caucasian | NA | NA | 84 | 108 | NIH criteria | PCR-SSCP | 4 | 59/63 | 23/42 | 2/3 | 0.194 |
Mao et al. [15] | 2000 | China | Asian | 28.0 ± 0.5 | 31.1 ± 1.1 | 118 | 54 | NIH criteria | PCR-RFLP | 6 | 88/37 | 29/13 | 1/4 | 0.089 |
Vural et al. [22] | 2010 | Turkey | Caucasian | 25 (17–39)a | 27 (18–39)a | 97 | 95 | Rotterdam criteria | PCR-RFLP | 8 | 78/77 | 16/15 | 3/3 | 0.055 |
Zhang et al. [16] | 2010 | China | Asian | 29.0 ± 1.5 | 30.0 ± 1.5 | 78 | 40 | Rotterdam criteria | Microarray | 7 | 72/36 | 6/4 | 0/0 | 0.739 |
Deepika et al. [17] | 2013 | India | Asian | NA | NA | 283 | 306 | Rotterdam criteria | ARMS PCR | 6 | 10/10 | 270/293 | 3/3 | <0.05 |
Wen et al. [18] | 2013 | China | Asian | 26.86 ± 4.5 | 27.3 ± 3.71 | 103 | 59 | Rotterdam criteria | PCR-RFLP | 8 | 89/52 | 14/7 | 0/0 | 0.628 |
Grech et al. [19] | 2014 | Greece | Caucasian | 22.5 ± 3.2 | NA | 39 | 140 | Rotterdam criteria | PCR-RFLP | 5 | 33/125 | 6/14 | 0/1 | 0.394 |
IL-6 (−174 G/C) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Walch et al. [20] | 2004 | Austria | Caucasian | 28 (20–39)a | NA | 62 | 94 | Rotterdam criteria | Pyrosequencing | 6 | 24/43 | 30/35 | 8/16 | 0.068 |
Erdogan et al. [21] | 2009 | Turkey | Caucasian | 24.07 ± 1.32 | 25.01 ± 2.05 | 88 | 119 | Rotterdam criteria | PCR-RFLP | 8 | 57/32 | 26/75 | 5/12 | <0.05 |
Vural et al. [22] | 2010 | Turkey | Caucasian | 25 (17–39)a | 27 (18–39)a | 97 | 95 | Rotterdam criteria | PCR-RFLP | 8 | 59/46 | 34/42 | 4/7 | 0.536 |
Tumu et al. [23] | 2013 | India | Asian | 26.35 ± 3.88 | 30.00 ± 5.17 | 104 | 156 | Rotterdam criteria | Pyrosequencing | 6 | 69/77 | 31/73 | 4/6 | <0.05 |
IL-1beta (−511 C/T) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Kolbus et al. [24] | 2007 | Austria | Caucasian | 27.9 ± 5.0 | 28.8 ± 5.9 | 105 | 102 | Rotterdam criteria | Pyrosequencing | 7 | 43/40 | 47/48 | 15/14 | 0.947 |
Yang et al. [25] | 2009 | China | Asian | NA | NA | 118 | 86 | Rotterdam criteria | PCR-RFLP | 5 | 30/34 | 56/26 | 32/26 | <0.05 |
Mu et al. [26] | 2010 | China | Asian | 26.91 ± 4.02 | 31.14 ± 4.22 | 200 | 177 | Rotterdam criteria | PCR-RFLP | 6 | 64/26 | 76/87 | 60/64 | 0.684 |
Xia et al. [7] | 2013 | China | Asian | 29.75 ± 3.62 | 28.93 ± 3.91 | 59 | 56 | Rotterdam criteria | PCR-RFLP | 6 | 13/18 | 21/31 | 25/7 | 0.257 |