Comparison | No. of studies | C vs. G | CC vs. GG | GC vs. GG | CC + GC vs. GG | CC vs. GC + GG | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P H | OR (95% CI) | P H | OR (95% CI) | P H | OR (95% CI) | P H | OR (95% CI) | P H | ||
Overall | 4 | 0.63 (0.41-0.96)R | 0.013 | 0.52 (0.30-0.93)F | 0.329 | 0.54 (0.25-1.17)R | <0.01 | 0.53 (0.26-1.08)R | <0.01 | 0.67 (0.39-1.16)F | 0.881 |
HWE in controls/sample size ≤ 200 | 2 | 0.84 (0.60-1.16)F | 0.157 | 0.69 (0.32-1.50)F | 0.398 | 0.97 (0.40-2.31)R | 0.057 | 0.88 (0.41-1.92)R | 0.074 | 0.65 (0.31-1.37)F | 0.716 |
Sample size > 200a | 2 | 0.47 (0.28-0.80)R | 0.091 | 0.38 (0.17-0.89)F | 0.189 | 0.31 (0.13-0.74)R | 0.033 | 0.32 (0.13-0.78)R | 0.074 | 0.69 (0.30-1.59)F | 0.469 |
Caucasian | 3 | 0.63 (0.34-1.17)R | <0.01 | 0.48 (0.26-0.91)F | 0.211 | 0.57 (0.18-1.78)R | <0.01 | 0.54 (0.19-1.55)R | <0.01 | 0.61 (0.33-1.13)F | 0.897 |
Genotyping method | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
PCR-RFLP | 2 | 0.49 (0.27-0.88)R | 0.065 | 0.31 (0.13-0.72)F | 0.461 | 0.35 (0.11-1.11)R | <0.01 | 0.35 (0.12-1.03)R | <0.01 | 0.54 (0.24-1.23)F | 0.994 |
Pyrosequencing | 2 | 0.80 (0.47-1.37)R | 0.092 | 0.84 (0.38-1.84)F | 0.824 | 0.83 (0.26-2.64)R | <0.01 | 0.80 (0.30-2.10)R | 0.019 | 0.81 (0.38-1.70)F | 0.687 |