Association of TNF-alpha, IL-6 and IL-1beta gene polymorphisms with polycystic ovary syndrome: a meta-analysis

BMC Genomic Data

Table 3 Meta-analysis of IL-6 (−174 G/C) polymorphism and PCOS risk

Comparison	No. of studies	C vs. G		CC vs. GG		GC vs. GG		CC + GC vs. GG		CC vs. GC + GG
Comparison	No. of studies	OR (95% CI)	P _H	OR (95% CI)	P _H	OR (95% CI)	P _H	OR (95% CI)	P _H	OR (95% CI)	P _H
Overall	4	0.63 (0.41-0.96)^R	0.013	0.52 (0.30-0.93)^F	0.329	0.54 (0.25-1.17)^R	<0.01	0.53 (0.26-1.08)^R	<0.01	0.67 (0.39-1.16)^F	0.881
HWE in controls/sample size ≤ 200	2	0.84 (0.60-1.16)^F	0.157	0.69 (0.32-1.50)^F	0.398	0.97 (0.40-2.31)^R	0.057	0.88 (0.41-1.92)^R	0.074	0.65 (0.31-1.37)^F	0.716
Sample size > 200^a	2	0.47 (0.28-0.80)^R	0.091	0.38 (0.17-0.89)^F	0.189	0.31 (0.13-0.74)^R	0.033	0.32 (0.13-0.78)^R	0.074	0.69 (0.30-1.59)^F	0.469
Caucasian	3	0.63 (0.34-1.17)^R	<0.01	0.48 (0.26-0.91)^F	0.211	0.57 (0.18-1.78)^R	<0.01	0.54 (0.19-1.55)^R	<0.01	0.61 (0.33-1.13)^F	0.897
Genotyping method
PCR-RFLP	2	0.49 (0.27-0.88)^R	0.065	0.31 (0.13-0.72)^F	0.461	0.35 (0.11-1.11)^R	<0.01	0.35 (0.12-1.03)^R	<0.01	0.54 (0.24-1.23)^F	0.994
Pyrosequencing	2	0.80 (0.47-1.37)^R	0.092	0.84 (0.38-1.84)^F	0.824	0.83 (0.26-2.64)^R	<0.01	0.80 (0.30-2.10)^R	0.019	0.81 (0.38-1.70)^F	0.687

OR, odds ratio; CI, confidence interval; No., number; vs.: versus; P _H, p value of Q-test for heterogeneity test; ^Rrandom-effect model; ^Ffixed-effect model; ^adeviated from HWE in controls.

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