Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

BMC Genomic Data

Table 4 The effects of amino acids on lifespan of rsks-1 , gcn-2 , ife-2 , gas-1 , and mev-1 mutants

Strain	Treatment	% of N2 control mean lifespan	% of untreated mean lifespan	p-value	# of worms	Replicates
rsks-1(ok1255)	Control	109		<0.001	362	4
	1 mM tryptophan		71	<0.001	130	2
	5 mM histidine		93	0.031	135	2
	5 mM proline		94	0.042	140	2
	10 mM serine		101	0.236	162	2
gcn-2(ok871)	Control	90		<0.001	479	4
	1 mM tryptophan		99	0.489	160	2
	5 mM histidine		100	0.335	163	2
	5 mM proline		107	0.001	205	2
	10 mM serine		104	0.006	183	2
Ife-2(ok306)	Control	97		0.245	112	2
	1 mM tryptophan		94	0.029	138	2
	5 mM histidine		98	0.597	110	2
	5 mM proline		102	0.352	117	2
	10 mM serine		99	0.791	96	2
gas-1(fc21)	Control	69		<0.001	119	2
	5 mM histidine		104	0.092	110	2
	10 mM serine		98	0.327	106	2
	5 mM proline		109	0.003	115	2
mev-1(kn1)	Control	69		<0.001	273	2
	5 mM histidine		104	0.021	215	2
	10 mM serine		109	<0.001	258	2
	5 mM proline		102	0.102	256	2

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