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Table 10 Power and family-wise error rate (FWER) of FORCE, MBMDR, Plink Epistasis and Plink FastEpistasis on 6 epistasis models without noise or with simulated genetic heterogeneity (GH)

From: Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

   

Model 1

Model 2

Model 3

Model 4

Model 5

Model 6

   

Both

First

Either

Both

First

Either

Both

First

Either

Both

First

Either

Both

First

Either

Both

First

Either

FORCE

Powera

0.01

0.08

0.14

0.38

0.6

0.82

0.03

0.19

0.34

0.16

0.39

0.62

0.04

0.21

0.38

0.1

0.34

0.57

FWERb

0.02

0.07

0.07

0.04

0.02

0.02

MBMDR

Power

0.75

0.86

0.97

0.96

0.98

1

0

0.09

0.17

0.01

0.07

0.13

0

0.07

0.13

0.03

0.16

0.28

FWER

0

0

0

0

0

0

Plink

Epistasis

Power

0

0

0

0.91

0.96

1

0

0.02

0.03

0.05

0.29

0.52

0

0.13

0.26

0.02

0.25

0.47

FWER

0.01

0.02

0.01

0.05

0

0

FastEpistasis

Power

0

0

0

0.96

0.98

1

0

0.02

0.04

0.08

0.31

0.54

0

0.07

0.14

0.02

0.18

0.34

FWER

0.02

0.03

0.01

0.07

0.01

0

  1. aIn bold, power higher than 50%. bIn bold, FWER lower than 5%.