Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

Table 11 Power of FORCE detection method, impact of various sources of noise and combinations of them for the 6 epistatic models

Type of noise	Model 1 ^a			Model 2			Model 3			Model 4			Model 5			Model 6
No noise	1			0.97			0.96			1			0.93			0.99
Genotype errors (GE)	0.99			0.99			0.97			1			0.95			0.99
Phenocopy (PC)	0.08			0.55			0.13			0.33			0.23			0.37
Misssing data (MS)	0.99			0.96			0.95			1			0.93			0.99
GE + PC	0.05			0.62			0.18			0.3			0.31			0.35
GE + MS	0.95			0.98			0.96			1			0.91			0.99
PC + MS	0.06			0.52			0.21			0.31			0.21			0.26
GE + PC + MS	0.09			0.55			0.21			0.46			0.13			0.35
	both	first	either	both	first	either	both	first	either	both	first	either	both	first	either	both	first	either
Genetic heterogeneity (GH)	0.01	0.08	0.14	0.38	0.6	0.82	0	0.19	0.34	0.2	0.39	0.62	0	0.21	0.38	0.1	0.34	0.57
GH + GE	0.01	0.09	0.16	0.34	0.6	0.85	0.03	0.18	0.32	0.17	0.4	0.62	0.04	0.23	0.41	0.14	0.31	0.50
GH + PC	0	0.015	0.03	0.02	0.09	0.16	0	0.01	0.02	0	0.02	0.04	0.01	0.035	0.06	0.01	0.04	0.07
GH + MS	0.01	0.04	0.07	0.37	0.57	0.77	0.02	0.145	0.27	0.18	0.385	0.59	0.03	0.19	0.35	0.07	0.28	0.50
GH + GE + PC	0	0.01	0.02	0.03	0.105	0.18	0	0.02	0.04	0	0.025	0.05	0	0.025	0.05	0	0.03	0.06
GH + GE + MS	0	0.05	0.1	0.33	0.665	0.80	0.02	0.155	0.29	0.13	0.385	0.64	0.03	0.23	0.43	0.13	0.305	0.48
GH + PC + MS	0	0.005	0.01	0.01	0.095	0.18	0	0.025	0.05	0	0.04	0.08	0	0.005	0.01	0	0.035	0.07
GH + GE + PC + MS	0	0.015	0.03	0.01	0.08	0.15	0	0.015	0.03	0	0.035	0.07	0	0.015	0.03	0	0.03	0.06

GE: Genotyping errors – GH: Genetic heterogeneity – MS: Missing data – PC: Phenocopy. In case of GH, power is calculated in 3 different ways as the proportion of datasets in which both, the first or either of the interacting pairs are detected. ^aIn bold, power higher than 50%.

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