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Table 4 Average time needed to exhaustively test one/all 1.25×10 11 pairs among 500,000 SNPs using a single-core CPU computer

From: Filter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis

Software

Time for one/all SNPs (single core)

MB-MDR [16]

5×10-3 s/20 years [31]

PLINK Epistasis [7]

2×10-4 s/289 days [5]

PLINK FastEpistasis [8]

2×10-5 s/29 days [32]

FORCE

3×10-6 s/4.3 days

GWIS - 3 filters [33]

1.6×10-6 s/2.2 days [33]

GWIS - 1 filter [33]

3.8×10-7 s/0.5 days [33]

  1. We included the recent GWIS approach that is described as ‘exhaustive’, but uses filtering to avoid computing test statistics for all pairs of SNPs.