Figure 3

Highly interconnected networks of loop motifs related to early (24 h) and late (7d) post-IR injury periods. A. Regulatory network at 24 h consisting of 2681 closed loop-motifs, with only 45 in common with the 7d time point. B. Regulatory network at 7d consisting of 699 closed loop-motifs, with only 45 in common with the 24 h time point. Each motif is composed by a microRNA (miR, filled green circle) a transcription factor (TF, filled red circle) and a related protein-coding gene transcript (filled blue circle). Every node (miRNA, TF and TG) represents a differentially expressed molecular element with altered expression in retinal ischemia-reperfusion injury, when compared to sham control animals.