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Table 4 Top ten transcription factors, mRNAs and miRs ranked by the number of their connections at the 2 time points 24 h and 7d post-IR injury

From: Regulatory networks in retinal ischemia-reperfusion injury

miR (24 h)

C

miR (7d)

C

mRNA (24 h)

C

mRNA (7d)

C

TF (24 h)

C

TF (7d)

C

miR-495*

172

miR-873

55

Dhcr24

22

Igf1

21

Maf

389

Lef1

124

miR-214

170

miR-223

48

Map2

22

Prrx1

16

Stat1

165

Stat1

106

miR-207

143

miR-410

45

Hmox1

21

Xpr1

16

Creb1

104

Bcl6

98

miR-298

132

miR-185

45

Pcdha4

21

Dhcr24

14

Nptx1

29

Stat3

12

miR-466b

111

miR-291a-3p

44

Foxp1

21

Slc26a4

14

Tp53

28

Runx1

8

miR-206

104

miR-495

43

Samd12

20

Glce

13

Foxp1

21

Cebpb

8

miR-19a

102

miR-329

40

Kcnc1

19

Slc18a2

13

Isl1

18

Litaf

7

miR-221

95

miR-207

35

Ppp1r9a

19

Stat3

12

Nr2c2

15

Arida5a

6

miR-297

91

miR-138

31

Rictor

19

Fut4

12

Gnb1

12

Lgals3

4

miR-33

90

miR-539

28

Dclk1

19

Scarb2

12

Rnf138

7

Arpc1b

3

  1. *Bold denotes the common molecular components between the early and late post-IR time points.
  2. We have rank-ordered each of the 3 molecular components by their relative connectivity and used this as a marker of relative importance within networks at the 2 time points. Note that there are a few molecular components which are common to both time points. For example rno-miR-495 and rno-miR-207 are common between the 24 h and 7d time points, but they are rank-ordered differently between the 2 time points. In addition, Stat1 is present and equally rank-ordered at both time points. C = number of connections.