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Table 4 Area under receiver operating characteristic curve by subtype of CRC: Korean Cancer Prevention Study II sub-cohort

From: A colorectal cancer prediction model using traditional and genetic risk scores in Koreans

   Colorectal cancer Colon cancer Rectal cancer
   HR (95% CI) HR (95% CI)* HR (95% CI) HR (95% CI)* HR (95% CI) HR (95% CI)*
TRS Q1 1.00 1.00 1.00 1.00 1.00 1.00
  Q2 1.97 (0.95-4.11) 2.03 (0.98-4.22) 1.60 (0.52-4.94) 1.60 (0.52-4.95) 2.28 (0.87-6.01) 2.40 (0.91-6.31)
  Q3 2.57 (1.29-5.14) 2.62 (1.31-5.24) 2.19 (0.76-6.32) 2.16 (0.75-6.24) 2.88 (1.15-7.24) 3.02 (1.20-7.59)
  Q4 11.29 (6.06-21.1) 11.54 (6.19-21.5) 13.33 (5.31-33.5) 13.27 (5.29-33.3) 10.16 (4.36-23.7) 10.59 (4.54-24.7)
GRS Q1   1.00   1.00   1.00
  Q2   1.42 (0.77-2.61)   0.95 (0.47-1.91)   3.95 (0.93-16.84)
  Q3   1.68 (0.92-3.07)   0.77 (0.37-1.59)   7.06 (1.70-29.28)
  Q4   2.65 (1.43-4.91)   1.17 (0.55-2.50)   10.83 (2.58-45.40)
AUROC   0.73 (0.69-0.78) 0.74 (0.70-0.78) 0.76 (0.70-0.83) 0.75 (0.69-0.81) 0.71 (0.65-0.77) 0.74 (0.68-0.79)
NRI   - 0.17 (-0.05-0.37)   −0.17 (-0.33-0.21) - 0.41 (0.10-0.68)
P for NRI   0.108   0.688   0.008
  1. CRC: colorectal cancer, TRS: traditional risk score, GRS: genetic risk score, HR: hazard ratio, CI: confidence interval, AUROC: Area under receiver operating characteristic curve, NRI: net reclassification index.
  2. *Combined model, AUROC for TRS alone, AUROC for TRS + GRS.