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Table 3 Size and power of tests for gene-gene interactions

From: Jackknife-based gene-gene interaction tests for untyped SNPs

Model

WTT

WTT c

Dosage/

Dosage/

Truth/

Truth/

   

WTT

WTT c

WTT

WTT c

Null

0.011

0.010

0

0

0.006

0.008

D ∪D

0.14

0.16

0

0.04

0.56

0.60

R ∪R

0.17

0.21

0.02

0.03

0.86

0.94

D ∪R

0.15

0.17

0.04

0.08

0.70

0.77

R ∩D

0.15

0.17

0.02

0.03

0.71

0.77

R ∩R

0.22

0.25

0.03

0.04

0.81

0.84

D ∩D

0.13

0.14

0.01

0.04

0.73

0.76

  1. M D for markers G and H using the HapMap CEU samples are 0.7266 and 0.7345, respectively. WTT and WTT c correspond to tests (5) and (6) where V 0u was estimated by applying the jackknife on imputed values. Dosage/WTT and Truth/WTT are test (4) using the asymptotic variance based on expected genotypes and true genotypes, respectively. Dosage/ WTT c and Truth/ WTT c are ICPT on expected genotypes and true genotypes, respectively. Models are described in Table 1. Number of individuals in cases is 5000. Significance levels for size and power are 0.01 and 0.05, respectively. WTT, Wald-type test; WTT c test, Wald-type test with constraints